{"id":"W1906457741","doi":"10.1016/j.radonc.2015.08.003","title":"In vivo studies of the PARP inhibitor, AZD-2281, in combination with fractionated radiotherapy: An exploration of the therapeutic ratio","year":2015,"lang":"en","type":"article","venue":"Radiotherapy and Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Canadian Cancer Society Research Institute; Deutsche Krebshilfe; Ontario Ministry of Health and Long-Term Care; Prostate Cancer Canada","keywords":"Clonogenic assay; Cancer research; In vivo; Radiation therapy; Prostate cancer; PARP inhibitor; Medicine; Cancer; Chemistry; Internal medicine; Poly ADP ribose polymerase; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006541614,0.0001569028,0.0004794115,0.0001631781,0.00005581216,0.000005978938,0.0001091661,0.0001537997,0.0000360478],"category_scores_gemma":[0.00003602326,0.00009111848,0.0000464351,0.0005736792,0.0004643994,0.0004162189,0.00001042093,0.0002358922,1.519488e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007953897,"about_ca_system_score_gemma":0.0004210464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001158371,"about_ca_topic_score_gemma":0.0007701373,"domain_scores_codex":[0.9983033,0.0005845684,0.0004569918,0.0002178677,0.0002852336,0.0001520505],"domain_scores_gemma":[0.9989185,0.0001934371,0.0003360221,0.0002993379,0.0002086163,0.00004404864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01477919,0.004484248,0.2339447,0.0002630871,0.0008957792,0.00002148321,0.1032025,0.004561196,0.5925562,0.01354949,0.002364242,0.02937781],"study_design_scores_gemma":[0.1337782,0.02559274,0.2015243,0.001590675,0.0002795752,0.000422784,0.02620014,0.01181775,0.4595761,0.02884056,0.1092371,0.001140118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979511,0.006110546,0.0009413737,0.01165999,0.0005101506,0.00106093,0.000004664341,0.00001625813,0.0001850729],"genre_scores_gemma":[0.9947544,0.002280552,0.0004472503,0.002123541,0.0001200245,0.0001093276,0.000002263275,0.00002339939,0.0001392951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1329801,"threshold_uncertainty_score":0.3715704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.084946706541947,"score_gpt":0.3800376252545269,"score_spread":0.2950909187125799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}