{"id":"W1906739144","doi":"10.4049/jimmunol.164.6.2881","title":"A Population of In Vivo Anergized T Cells with a Lower Activation Threshold for the Induction of CD25 Exhibit Differential Requirements in Mobilization of Intracellular Calcium and Mitogen-Activated Protein Kinase Activation","year":2000,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Medical Research Council; Medical Research Council Canada; Arthritis Society","keywords":"Cell biology; IL-2 receptor; T cell; T-cell receptor; Biology; Jurkat cells; CD28; Cytotoxic T cell; ZAP70; Population; Intracellular; FYN; Signal transduction; Molecular biology; Immunology; Immune system; Biochemistry; In vitro; Proto-oncogene tyrosine-protein kinase Src; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000185055,0.0003186709,0.000319779,0.0002905645,0.0001877913,0.0004047193,0.0001864823,0.0002886221,0.001389107],"category_scores_gemma":[0.0001113249,0.0001184152,0.0002165034,0.0001096186,0.0001787832,0.0002149404,0.0002058819,0.0009372592,0.0002950533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000170022,"about_ca_system_score_gemma":0.000102544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001482996,"about_ca_topic_score_gemma":0.0001712879,"domain_scores_codex":[0.9998214,0.00001943226,0.00002377956,0.00005401496,0.00003622819,0.00004513308],"domain_scores_gemma":[0.9998007,0.00003678636,0.00004358044,0.00002946107,0.00001981347,0.00006960615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006967154,0.00003746334,0.0001774128,0.000007712057,0.00000314414,0.00003547062,0.000009428504,0.00001796371,0.9992112,0.00004556469,0.000007682547,0.0003773697],"study_design_scores_gemma":[0.00009384084,0.00130636,0.02003129,0.00001313379,0.0000837858,0.001733187,0.0001029646,0.001452625,0.973181,0.0001874605,0.001797354,0.00001694981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997071,0.0002945157,0.001684139,0.0000449535,0.00001167562,0.00002582645,0.0001098701,0.00002349028,0.0007345264],"genre_scores_gemma":[0.9956779,0.0001730678,0.001717498,0.00007328614,0.0000253834,0.00005689569,0.0003008516,0.00001548847,0.001959582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001389107,"threshold_uncertainty_score":0.004647076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01666382999586596,"score_gpt":0.2384623944189821,"score_spread":0.2217985644231161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}