{"id":"W1906739144","doi":"10.4049/jimmunol.164.6.2881","title":"A Population of In Vivo Anergized T Cells with a Lower Activation Threshold for the Induction of CD25 Exhibit Differential Requirements in Mobilization of Intracellular Calcium and Mitogen-Activated Protein Kinase Activation","year":2000,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Medical Research Council; Medical Research Council Canada; Arthritis Society","keywords":"Cell biology; IL-2 receptor; T cell; T-cell receptor; Biology; Jurkat cells; CD28; Cytotoxic T cell; ZAP70; Population; Intracellular; FYN; Signal transduction; Molecular biology; Immunology; Immune system; Biochemistry; In vitro; Proto-oncogene tyrosine-protein kinase Src; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004829112,0.0001359025,0.000352367,0.0003028632,0.00006279582,0.000004198098,0.0001237278,0.0002035016,0.0002955584],"category_scores_gemma":[0.00007029369,0.00008545939,0.00005900947,0.0002803253,0.0001766274,0.0003074191,0.00001774513,0.0003072504,4.32006e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008727711,"about_ca_system_score_gemma":0.00004425949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005761235,"about_ca_topic_score_gemma":0.00003217435,"domain_scores_codex":[0.9985086,0.0003505991,0.000814777,0.0001101428,0.00007248418,0.0001433782],"domain_scores_gemma":[0.9983816,0.0001607417,0.001037875,0.0001764182,0.0002375137,0.000005822735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01826731,0.0003434333,0.0005703883,0.00003591943,0.000165405,1.751312e-7,0.0009960451,0.001296417,0.9760363,0.00004847755,0.00002014746,0.00222001],"study_design_scores_gemma":[0.004089754,0.001218188,0.01291376,0.0002577218,0.00006092808,0.00001812024,0.000732007,0.000240928,0.980233,0.00006324487,0.00009970624,0.00007270856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969397,0.0002792158,0.001489283,0.0001202741,0.0004374628,0.0007158354,0.000002137592,0.000003709002,0.00001235807],"genre_scores_gemma":[0.9995014,0.0001428732,0.00002064762,0.000008157003,0.00001636927,0.00001852638,0.00002036454,0.0000124387,0.0002592246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01417756,"threshold_uncertainty_score":0.3484933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01666382999586596,"score_gpt":0.2384623944189821,"score_spread":0.2217985644231161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}