{"id":"W1906870688","doi":"10.1186/s13073-015-0215-6","title":"Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing","year":2015,"lang":"en","type":"article","venue":"Genome Medicine","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":270,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Genome editing; Human genetics; Computational biology; DNA; CRISPR; Genome; Biology; Genetics; Medicine; Bioinformatics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003408541,0.0001524617,0.0002237024,0.000069147,0.00002790747,0.000003289841,0.0001047545,0.000113904,0.0001092447],"category_scores_gemma":[0.000223293,0.0001274933,0.00004160507,0.0001318382,0.0001170882,0.000002499061,0.00008694948,0.00009330381,0.00001343767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002039621,"about_ca_system_score_gemma":0.00003719882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001489562,"about_ca_topic_score_gemma":0.000003492813,"domain_scores_codex":[0.9989833,0.00003164925,0.0003045326,0.000244088,0.0001889847,0.000247464],"domain_scores_gemma":[0.9994211,0.00001864767,0.00008229771,0.0001616887,0.0001250128,0.0001912585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003818956,0.00002839918,0.0003271346,0.00002421156,0.00004068691,0.0000139167,0.000215637,0.00204823,0.9963006,0.000004571172,0.0007087555,0.0002496081],"study_design_scores_gemma":[0.007123748,0.003131998,0.01520701,0.00007666642,0.0002367994,0.0001204578,0.001383235,0.001364372,0.8771063,0.0001347015,0.09343833,0.0006763972],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892768,0.003798993,0.004868424,0.000355033,0.0003301805,0.0001805534,0.00002502676,0.00002528517,0.001139691],"genre_scores_gemma":[0.9972007,0.0001551205,0.0003361133,0.0002124415,0.0014585,0.00001064541,0.0004653192,0.00001916052,0.0001420018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1191944,"threshold_uncertainty_score":0.5199026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02076915456627666,"score_gpt":0.3143798195435453,"score_spread":0.2936106649772686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}