{"id":"W1906870688","doi":"10.1186/s13073-015-0215-6","title":"Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing","year":2015,"lang":"en","type":"article","venue":"Genome Medicine","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":270,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Genome editing; Human genetics; Computational biology; DNA; CRISPR; Genome; Biology; Genetics; Medicine; Bioinformatics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002295415,0.000437358,0.0004410794,0.0002509613,0.000118986,0.0003519687,0.0003475583,0.0003300593,0.002417849],"category_scores_gemma":[0.0002953063,0.0001449443,0.0002813879,0.0001605149,0.0003158675,0.0002399965,0.0002159356,0.0009090794,0.0005642489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003259084,"about_ca_system_score_gemma":0.0002677354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002271594,"about_ca_topic_score_gemma":0.0003413336,"domain_scores_codex":[0.9997733,0.00003588041,0.00003729834,0.00005211685,0.00006005734,0.00004136914],"domain_scores_gemma":[0.9997545,0.0000835863,0.0000772565,0.00002608736,0.00002336071,0.0000352364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000205088,0.00009544182,0.00009930287,0.0001078548,0.000009372868,0.00002460519,0.000004756684,0.00007849168,0.9981465,0.00007381125,0.0000412409,0.001113463],"study_design_scores_gemma":[0.00002012953,0.0002639355,0.000532637,0.000004056235,0.000009092717,0.00005400655,0.000003407753,0.0003500496,0.9981376,0.00002000292,0.0006031934,0.000001970275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799002,0.003970072,0.01059506,0.0003452266,0.0001568077,0.0001846602,0.0007710444,0.0003046375,0.003772264],"genre_scores_gemma":[0.9904501,0.001803444,0.005594582,0.00007160853,0.00002737087,0.0001018523,0.0005844351,0.00002509038,0.001341463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002417849,"threshold_uncertainty_score":0.008088529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02076915456627666,"score_gpt":0.3143798195435453,"score_spread":0.2936106649772686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}