{"id":"W1906905763","doi":"10.1093/brain/awv107","title":"The role of tau in the pathological process and clinical expression of Huntington’s disease","year":2015,"lang":"en","type":"article","venue":"Brain","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval; Université Laval; Centre hospitalier universitaire de Québec","funders":"NIHR Cambridge Biomedical Research Centre; Medical Research Council; Evelyn Trust; Parkinson's UK; CurePSP; National Institute for Health and Care Research; European Huntington's Disease Network; Université Laval","keywords":"Huntington's disease; Tauopathy; Huntingtin; Disease; Tau protein; Trinucleotide repeat expansion; Pathological; Huntingtin Protein; Dementia; Pathology; Biology; Allele; Medicine; Neuroscience; Alzheimer's disease; Neurodegeneration; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004966413,0.0003143019,0.000358244,0.0009280576,0.0003109672,0.0005586495,0.0002663692,0.000337531,0.0007554865],"category_scores_gemma":[0.001655928,0.0002157806,0.0001392229,0.0005698444,0.0006194439,0.0003982089,0.0004089074,0.0002955159,0.000189665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002165831,"about_ca_system_score_gemma":0.0001799774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009106178,"about_ca_topic_score_gemma":0.000896442,"domain_scores_codex":[0.9997129,0.00008434674,0.00004063491,0.00006613661,0.00006288499,0.00003306962],"domain_scores_gemma":[0.9990939,0.0002370112,0.0003824515,0.00005473642,0.00009902179,0.0001329106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001961376,0.0001713739,0.9093791,0.0001347485,0.0001530688,0.006274948,0.0007238618,0.0002234531,0.06496098,0.0002154452,0.000171472,0.01563026],"study_design_scores_gemma":[0.000009654492,0.0001506571,0.9950066,0.00001068639,0.00002468713,0.003022038,0.00009713769,0.000122737,0.001222224,0.0001442527,0.0001835948,0.000005712208],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9975846,0.00168456,0.000115438,0.00003733902,0.000005468034,0.000005121408,0.00004991227,0.000003489248,0.0005141355],"genre_scores_gemma":[0.9993273,0.0003963532,0.00008378118,0.00001407014,0.00001313991,0.000003270395,0.00005997355,0.000002323049,0.00009987431],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.0009280576,"threshold_uncertainty_score":0.002626538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05287163255788362,"score_gpt":0.3467266826067713,"score_spread":0.2938550500488876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}