{"id":"W1907272683","doi":"10.1158/1078-0432.ccr-15-0866","title":"siRNA Lipid Nanoparticle Potently Silences Clusterin and Delays Progression When Combined with Androgen Receptor Cotargeting in Enzalutamide-Resistant Prostate Cancer","year":2015,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Clusterin; LNCaP; Enzalutamide; Prostate cancer; Cancer research; Androgen receptor; Gene silencing; Medicine; In vivo; Apoptosis; Chemistry; Cancer; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001125092,0.0002950331,0.0002824994,0.0001959519,0.000128998,0.0002250414,0.0001815441,0.0002066273,0.0005042667],"category_scores_gemma":[0.00006570279,0.0001004736,0.0002042094,0.0001474593,0.0002054895,0.0001452426,0.0001160576,0.0002928782,0.0001372939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004328237,"about_ca_system_score_gemma":0.0004075339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001780848,"about_ca_topic_score_gemma":0.003207369,"domain_scores_codex":[0.9999089,0.00001133079,0.000006333391,0.0000226507,0.00003133369,0.00001941214],"domain_scores_gemma":[0.9999647,0.000004185611,0.00001056933,0.000003129259,0.000007083871,0.00001033954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001497983,0.00006557038,0.00007511025,0.00004014833,0.000005972402,0.00002698956,0.00001653215,0.0001892239,0.9974503,0.0000515184,0.00007071315,0.001858187],"study_design_scores_gemma":[0.00003183365,0.0008322003,0.001002558,0.000002605858,0.00002079301,0.00008960475,0.00001091638,0.0009702505,0.995666,0.000009486454,0.001359768,0.000004002142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952922,0.000937886,0.002165619,0.00006910734,0.00002486337,0.00006654341,0.0001455827,0.0001222226,0.00117602],"genre_scores_gemma":[0.9953842,0.0005502889,0.001705684,0.00002579844,0.000005030051,0.00005452772,0.0001916884,0.00001753484,0.002065392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001780848,"threshold_uncertainty_score":0.003540993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1682134913573449,"score_gpt":0.4806860595481425,"score_spread":0.3124725681907976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}