{"id":"W1907405942","doi":"10.4049/jimmunol.175.12.8123","title":"T Cell Activation-Induced CrkII Binding to the Zap70 Protein Tyrosine Kinase Is Mediated by Lck-Dependent Phosphorylation of Zap70 Tyrosine 315","year":2005,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Ontario Institute for Cancer Research","funders":"Israel Science Foundation; German-Israeli Foundation for Scientific Research and Development; Israel Cancer Association; Israel Cancer Research Fund","keywords":"ZAP70; Tyrosine phosphorylation; Signal transducing adaptor protein; Cell biology; Signal transduction; Phosphorylation; T-cell receptor; Tyrosine kinase; Tyrosine; Biology; T cell; Biochemistry; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008647466,0.0002918368,0.000216933,0.0001656479,0.0002472166,0.0003521585,0.0002199372,0.0002010814,0.001939478],"category_scores_gemma":[0.0001135044,0.0001515665,0.0003819404,0.000155911,0.0001734929,0.0001425154,0.0004142012,0.000540414,0.0007467015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006160769,"about_ca_system_score_gemma":0.0002443987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001105555,"about_ca_topic_score_gemma":0.0008726943,"domain_scores_codex":[0.9997866,0.00001652634,0.00001083737,0.00003304746,0.00004214413,0.0001109019],"domain_scores_gemma":[0.9999239,0.00000819264,0.00001916667,0.000006332442,0.000007705968,0.00003456705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001058558,0.00001919803,0.0001246035,0.00003360106,0.000003285239,0.00006334026,0.00001017273,0.00002270292,0.9990276,0.00007626411,0.00003594774,0.0004772907],"study_design_scores_gemma":[0.00003251646,0.0001284104,0.02027051,0.00001164991,0.0000113444,0.0003606919,0.00003289988,0.001544439,0.9752741,0.00008423647,0.002241094,0.000007958721],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948404,0.001171868,0.00137526,0.00006229292,0.00002935413,0.00002826013,0.0002147251,0.00005550347,0.002222207],"genre_scores_gemma":[0.9966722,0.0004676891,0.0005996279,0.00005804113,0.0000117952,0.00002799791,0.0004097726,0.00001166707,0.001741181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001939478,"threshold_uncertainty_score":0.006488204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01155267591070049,"score_gpt":0.2244090497749533,"score_spread":0.2128563738642528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}