{"id":"W1908864745","doi":"10.1016/j.cell.2015.09.033","title":"Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer","year":2015,"lang":"en","type":"article","venue":"Cell","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1960,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; BC Cancer Agency","funders":"U.S. National Library of Medicine; National Institute of General Medical Sciences; National Cancer Institute","keywords":"Biology; Invasive lobular carcinoma; FOXA1; PTEN; Cancer research; Breast cancer; GATA3; PI3K/AKT/mTOR pathway; Cancer; Invasive ductal carcinoma; Genetics; Gene; Transcription factor; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001691889,0.0001703465,0.0002427542,0.001035559,0.0002656712,0.0006731883,0.0002102118,0.0002340253,0.001726959],"category_scores_gemma":[0.0001304,0.0001321745,0.0001293324,0.0007038688,0.0001866163,0.0003705681,0.0003109361,0.000508527,0.0005788832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002400871,"about_ca_system_score_gemma":0.0002210702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005213468,"about_ca_topic_score_gemma":0.00115136,"domain_scores_codex":[0.9999207,0.000007706471,0.000005074844,0.00001444129,0.00003282278,0.00001916044],"domain_scores_gemma":[0.9999267,0.00001543462,0.00001289406,0.00001561559,0.0000147164,0.00001474752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001727564,0.00002208403,0.007207052,0.0001390739,0.00002535813,0.0005692228,0.0003011365,0.000392743,0.9647143,0.001851523,0.001137475,0.02346732],"study_design_scores_gemma":[0.00003585836,0.0003460432,0.3459637,0.00011374,0.000299355,0.01601974,0.002338013,0.00355513,0.4358417,0.00754976,0.1879014,0.00003550112],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9366116,0.02480792,0.0117149,0.001666641,0.00005368145,0.00005302519,0.006152365,0.0003487422,0.01859118],"genre_scores_gemma":[0.9744928,0.01102821,0.003669781,0.0003865923,0.00004504601,0.00003329848,0.003993309,0.0000459872,0.006304988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001726959,"threshold_uncertainty_score":0.00577724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01321610313784085,"score_gpt":0.2384809756747396,"score_spread":0.2252648725368987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}