{"id":"W1909117315","doi":"10.1074/jbc.m115.662114","title":"Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":329,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"","keywords":"Metformin; Rotenone; AMPK; Chemistry; Reactive oxygen species; Lipopolysaccharide; Pharmacology; Cytokine; Mitochondrial ROS; Protein kinase A; Mitochondrion; Biochemistry; Biology; Endocrinology; Internal medicine; Kinase; Medicine; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001397188,0.0003658255,0.0003085374,0.0002349109,0.0001301913,0.000172956,0.0001977133,0.0002529969,0.0007732371],"category_scores_gemma":[0.0001033279,0.0001305651,0.0002716558,0.000138816,0.0001011024,0.0001430563,0.000139543,0.0005375067,0.0001758168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001498887,"about_ca_system_score_gemma":0.0001966612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002088371,"about_ca_topic_score_gemma":0.0005142907,"domain_scores_codex":[0.9999046,0.00001559278,0.00001648668,0.00001400393,0.00002581954,0.00002342222],"domain_scores_gemma":[0.9999337,0.000007966126,0.00002692786,0.000004965706,0.000007875571,0.00001851532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008955509,0.0002068315,0.000247891,0.0001683513,0.00001827554,0.00004513961,0.000008081525,0.00009114062,0.9924274,0.00006702871,0.0001240742,0.005700313],"study_design_scores_gemma":[0.0003871254,0.003745873,0.008641463,0.00002098426,0.00005851312,0.000257768,0.00001890887,0.0009166592,0.9811093,0.00006502831,0.004769739,0.00000871677],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884758,0.007198992,0.002469154,0.0002257785,0.0001825683,0.0000726602,0.00031072,0.00007326403,0.0009911673],"genre_scores_gemma":[0.988638,0.005218905,0.003192514,0.0001470938,0.00005866251,0.00009820898,0.0005006022,0.00001197685,0.002134005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007732371,"threshold_uncertainty_score":0.002586782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03354077064383818,"score_gpt":0.2597540311961725,"score_spread":0.2262132605523343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}