{"id":"W1909274503","doi":"10.1111/ajt.12779","title":"RIPK3-Mediated Necroptosis Regulates Cardiac Allograft Rejection","year":2014,"lang":"en","type":"article","venue":"American Journal of Transplantation","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; London Health Sciences Centre; Western University","funders":"Canadian Institutes of Health Research; U.S. Public Health Service; London Health Sciences Centre","keywords":"Necroptosis; RIPK1; Programmed cell death; Transplantation; Medicine; Apoptosis; Cancer research; Tumor necrosis factor alpha; Necrosis; HMGB1; Immune system; Immunology; Cell biology; Pathology; Biology; Inflammation; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001868105,0.0003869639,0.0002798591,0.0001779902,0.000206029,0.0004460211,0.000187583,0.0003014564,0.001542739],"category_scores_gemma":[0.0001371531,0.0001240621,0.0003656883,0.0001068571,0.0003008535,0.0002402101,0.0002044161,0.0009746314,0.0005924891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003994676,"about_ca_system_score_gemma":0.0002536608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002484993,"about_ca_topic_score_gemma":0.0003885475,"domain_scores_codex":[0.9998498,0.00002368545,0.0000164638,0.00002882078,0.00003579699,0.00004545679],"domain_scores_gemma":[0.9998497,0.000009532785,0.00006866395,0.00000869128,0.00001482428,0.00004859373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003476133,0.00003186217,0.000491959,0.00005144601,0.000008330836,0.0000866044,0.00001289019,0.0000605881,0.9975905,0.00008436987,0.00006037077,0.001173493],"study_design_scores_gemma":[0.0001115329,0.0006613078,0.05364404,0.00003209722,0.00009599501,0.001649352,0.0001307012,0.002754887,0.9369256,0.0003883538,0.003582388,0.00002370116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924981,0.003043508,0.002278629,0.0001740691,0.00004219222,0.00002611784,0.0003304571,0.0001873254,0.001419512],"genre_scores_gemma":[0.996224,0.001010484,0.0009393772,0.00006916426,0.00001233406,0.00002467422,0.0002540727,0.00002842201,0.001437472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001542739,"threshold_uncertainty_score":0.005160987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002771398527239361,"score_gpt":0.2029589083732629,"score_spread":0.2001875098460235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}