{"id":"W1909297598","doi":"10.1039/c5cc05222j","title":"Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology","year":2015,"lang":"en","type":"article","venue":"Chemical Communications","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Medical Research Council; Cancer Research UK","keywords":"Sulfation; Interleukin 8; Chemokine; Heparan sulfate; Chemistry; Cell biology; Biochemistry; Biology; Immunology; Inflammation; Glycosaminoglycan; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001174621,0.0003262454,0.0001153181,0.00009987687,0.0000749395,0.0001897471,0.0000949646,0.0001511807,0.0006405498],"category_scores_gemma":[0.0001084405,0.0001020648,0.0001189083,0.000114969,0.0001556856,0.0001745115,0.0001182481,0.0003250823,0.0001816724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001597874,"about_ca_system_score_gemma":0.0001237248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001595131,"about_ca_topic_score_gemma":0.0003345273,"domain_scores_codex":[0.9999313,0.00001445793,0.000007538491,0.000009715869,0.0000208691,0.00001614663],"domain_scores_gemma":[0.9998932,0.00001423554,0.0000342794,0.00001359365,0.00001245189,0.00003227031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006401503,0.00001190464,0.00004761546,0.000008869678,0.00000138999,0.00001560199,0.000004585696,0.00005424012,0.9990883,0.00005786322,0.000005993242,0.0006395532],"study_design_scores_gemma":[0.000006731016,0.0003866188,0.0005029039,0.000001721085,0.000003606762,0.00007415548,0.000006851283,0.0001354035,0.9980779,0.00003237603,0.0007692672,0.000002427271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954105,0.0003060351,0.003331575,0.0000344986,0.00001564963,0.00003054488,0.0001239664,0.00003413699,0.0007130294],"genre_scores_gemma":[0.9926682,0.0004454541,0.005002879,0.00003166826,0.000006280985,0.00002546313,0.0003522176,0.00001765857,0.001450183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006405498,"threshold_uncertainty_score":0.002142847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06572513639695347,"score_gpt":0.3211304902339678,"score_spread":0.2554053538370143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}