{"id":"W1909733617","doi":"10.4049/jimmunol.181.4.2348","title":"Immunosuppressive Effect of Isopropanol: Down-Regulation of Cytokine Production Results from the Alteration of Discrete Transcriptional Pathways in Activated Lymphocytes","year":2008,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Immune system; NFAT; Enterotoxin; Cytokine; In vitro; Receptor; Biology; Population; Immunology; Pharmacology; Chemistry; Medicine; Transcription factor; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001003016,0.0003641894,0.0001808347,0.0001441582,0.00006529206,0.000172477,0.0001081496,0.0001569044,0.001106171],"category_scores_gemma":[0.000115372,0.00005030081,0.0001748975,0.0001000442,0.0002175878,0.0001757516,0.0001300595,0.0003591986,0.0002140475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001158404,"about_ca_system_score_gemma":0.0000969397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009517601,"about_ca_topic_score_gemma":0.0001541203,"domain_scores_codex":[0.9999264,0.00001566124,0.000006589501,0.00001266914,0.0000162483,0.00002242353],"domain_scores_gemma":[0.999884,0.00003288913,0.00003143206,0.00001557118,0.00001330727,0.00002272639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008422375,0.00002270729,0.0001959528,0.00002650061,0.000001417294,0.00004074072,0.000004683716,0.00001607478,0.9983885,0.00001395535,0.000005972151,0.001199259],"study_design_scores_gemma":[0.00001026232,0.0007061158,0.005448346,0.000006162746,0.00001193904,0.0002020944,0.00001478486,0.0001305398,0.992665,0.00002586774,0.0007774737,0.000001385446],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949662,0.002276578,0.001935937,0.00006814318,0.00002097854,0.00001712219,0.0001292505,0.00002511277,0.0005604968],"genre_scores_gemma":[0.9955418,0.00161562,0.001571528,0.00005656386,0.00003460609,0.00002456995,0.0002675476,0.000007235722,0.0008806255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001106171,"threshold_uncertainty_score":0.003700495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01198423088180135,"score_gpt":0.2143318261462648,"score_spread":0.2023475952644634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}