{"id":"W1910049290","doi":"10.1126/science.aab2006","title":"Disruption of histone methylation in developing sperm impairs offspring health transgenerationally","year":2015,"lang":"en","type":"article","venue":"Science","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":531,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Children's Hospital; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Offspring; DNA methylation; Histone; Biology; Epigenetics; Histone methylation; Chromatin; Methylation; Sperm; Genetics; Transgenerational epigenetics; Gene; Gene expression; Pregnancy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000130089,0.0002635568,0.0001934303,0.0002345689,0.000107158,0.0002151112,0.0002690546,0.0002901199,0.001577211],"category_scores_gemma":[0.0001295646,0.0001839343,0.0001662717,0.0000909806,0.0003045677,0.000149685,0.0002559113,0.0006143217,0.0002522151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001948947,"about_ca_system_score_gemma":0.000200047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004766885,"about_ca_topic_score_gemma":0.0009098467,"domain_scores_codex":[0.9998596,0.00002028948,0.00001261414,0.00004462846,0.00003776121,0.00002510485],"domain_scores_gemma":[0.9998319,0.00002754295,0.00005203518,0.00002495247,0.0000119062,0.00005155746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006879378,0.0000163594,0.0003969916,0.00001140983,0.000005511346,0.00005829511,0.00001536513,0.00003156088,0.9981174,0.00009744623,0.00001845373,0.001162462],"study_design_scores_gemma":[0.00001366336,0.0003565701,0.00990969,0.000006480919,0.0000267388,0.0003781785,0.00004685455,0.0005485606,0.9873148,0.0001058691,0.001287808,0.000004830046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952714,0.0007392994,0.002621253,0.0001052626,0.00003085506,0.000008064637,0.0002007393,0.0001386145,0.0008844835],"genre_scores_gemma":[0.9954067,0.0004443106,0.0007965132,0.00004480915,0.000004623148,0.000008278826,0.0001456079,0.00002212034,0.003126952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001577211,"threshold_uncertainty_score":0.005276263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0434258126945886,"score_gpt":0.3713402795539952,"score_spread":0.3279144668594066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}