{"id":"W1910049290","doi":"10.1126/science.aab2006","title":"Disruption of histone methylation in developing sperm impairs offspring health transgenerationally","year":2015,"lang":"en","type":"article","venue":"Science","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":531,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Children's Hospital; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Offspring; DNA methylation; Histone; Biology; Epigenetics; Histone methylation; Chromatin; Methylation; Sperm; Genetics; Transgenerational epigenetics; Gene; Gene expression; Pregnancy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001174478,0.00005235096,0.0000720098,0.00009711922,0.00004721445,0.00001028972,0.0001037786,0.00003065369,0.000001173225],"category_scores_gemma":[0.0001287038,0.0000529006,0.00001723471,0.0002815866,0.00009600578,0.00001146158,0.00002600335,0.00002593538,9.044171e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000883889,"about_ca_system_score_gemma":0.0007759404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005241625,"about_ca_topic_score_gemma":0.0003049988,"domain_scores_codex":[0.9992101,0.00003585094,0.0002074265,0.0001960827,0.0002180273,0.0001325007],"domain_scores_gemma":[0.9996076,0.000005142309,0.00008116749,0.0001162579,0.000127855,0.00006195137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008896295,0.00001423678,0.00797685,0.000008457428,0.000001012597,1.002231e-7,0.0003385379,0.003508377,0.98247,0.0006338448,0.000003073895,0.005036601],"study_design_scores_gemma":[0.0002775388,0.0001315561,0.1098825,0.0000165935,0.000001085718,6.570387e-7,0.00008103333,0.001374498,0.8865331,0.0005760128,0.001030841,0.00009450473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9501686,0.001156007,0.04792075,0.0003166634,0.0001130508,0.00008813983,0.000001663913,0.000003053588,0.0002320748],"genre_scores_gemma":[0.9885821,0.0001507661,0.01113169,0.00004408477,0.000037004,0.000003251329,0.00001957088,0.000003937545,0.00002760605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1019057,"threshold_uncertainty_score":0.2157224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0434258126945886,"score_gpt":0.3713402795539952,"score_spread":0.3279144668594066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}