{"id":"W191008510","doi":"10.4049/jimmunol.186.supp.53.24","title":"Promotion of the neutralization-competent structure of the HIV-1 gp41 membrane proximal external region when tethered to its native transmembrane domain, and expressed in the context of the plasma membrane: implications for vaccine design (53.24)","year":2011,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Simon Fraser University","funders":"","keywords":"Neutralization; Gp41; Epitope; Context (archaeology); Antigenicity; Monoclonal antibody; Ectodomain; Transmembrane protein; Transmembrane domain; Chemistry; Membrane; Biophysics; Molecular biology; Biology; Biochemistry; Antibody; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002252294,0.0002579712,0.0001538987,0.00009101912,0.0001170263,0.0004147864,0.0001981013,0.0003329574,0.0008154767],"category_scores_gemma":[0.0001749309,0.0001345427,0.0002180813,0.00007615308,0.000239622,0.0002232294,0.0002093329,0.0005548283,0.000284652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003879515,"about_ca_system_score_gemma":0.0001841066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005944601,"about_ca_topic_score_gemma":0.0007230503,"domain_scores_codex":[0.9998943,0.00002525424,0.00000801669,0.00001458153,0.00003061636,0.0000273115],"domain_scores_gemma":[0.9999123,0.00002926301,0.00002394672,0.00001195275,0.000009041757,0.00001345581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001099252,0.000005271007,0.00004785274,0.000007018575,0.000001117547,0.00001476987,0.000005742227,0.00005782743,0.9996279,0.0000619401,0.000004093758,0.0001554748],"study_design_scores_gemma":[0.00000882806,0.0001046577,0.001052121,0.00000289784,0.000005459129,0.0001625628,0.00001470533,0.0008273344,0.9970746,0.00003069046,0.0007137495,0.000002443206],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964818,0.0002265213,0.002682631,0.000042783,0.000007101529,0.00001571292,0.00007525942,0.00002053538,0.000447555],"genre_scores_gemma":[0.9962509,0.0001503134,0.002858551,0.00002696538,0.000003057428,0.00001115098,0.0001428383,0.000008002958,0.0005481742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008154767,"threshold_uncertainty_score":0.002814829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03546081637793098,"score_gpt":0.2525878910168478,"score_spread":0.2171270746389168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}