{"id":"W1913144304","doi":"10.1111/exd.12821","title":"Reduction in keratin aggregates in epidermolysis bullosa simplex keratinocytes after pretreatment with trimethylamine N‐oxide","year":2015,"lang":"en","type":"letter","venue":"Experimental Dermatology","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Centre de Santé et de Services Sociaux de Chicoutimi; Université du Québec à Chicoutimi","funders":"Fondation du Grand défi Pierre Lavoie","keywords":"Epidermolysis bullosa simplex; Dermatology; Keratin; Epidermolysis bullosa; Chemistry; Trimethylamine N-oxide; Trimethylamine; Keratin 14; Medicine; Pathology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0001911836,0.000589483,0.0007597565,0.0003546792,0.0000494278,0.00003768447,0.0002942846,0.001304977,0.00013249],"category_scores_gemma":[0.00005727734,0.0005050641,0.0001349768,0.0002316671,0.0003820357,0.000009442412,0.000213966,0.0008090377,0.00004498628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002042378,"about_ca_system_score_gemma":0.0002516377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003101456,"about_ca_topic_score_gemma":0.0001273282,"domain_scores_codex":[0.9964747,0.0008250357,0.0005979094,0.001056456,0.0002596352,0.0007862452],"domain_scores_gemma":[0.9989908,0.00004723027,0.0001748403,0.00061695,0.00007365266,0.00009647242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004031485,0.001526146,0.0223931,0.000236272,0.0009467929,0.06642256,0.001066917,0.00004864262,0.56528,0.00001612401,0.3361663,0.001865666],"study_design_scores_gemma":[0.002929677,0.0007129179,0.0003047889,0.00007512259,0.00002815144,0.01097043,0.0003465974,0.00003406205,0.914268,0.0000332589,0.06961134,0.0006856231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9481446,0.03097426,0.00001532257,0.01912923,0.0001710691,0.0009119692,0.00004211658,0.00002254043,0.0005889072],"genre_scores_gemma":[0.9810115,0.0003734431,0.0008644136,0.01000331,0.0005497289,0.001225536,0.004024003,0.0001069914,0.001841118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.348988,"threshold_uncertainty_score":0.9999915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01475050713073921,"score_gpt":0.2815283107239852,"score_spread":0.266777803593246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}