{"id":"W1913144304","doi":"10.1111/exd.12821","title":"Reduction in keratin aggregates in epidermolysis bullosa simplex keratinocytes after pretreatment with trimethylamine N‐oxide","year":2015,"lang":"en","type":"letter","venue":"Experimental Dermatology","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Centre de Santé et de Services Sociaux de Chicoutimi; Université du Québec à Chicoutimi","funders":"Fondation du Grand défi Pierre Lavoie","keywords":"Epidermolysis bullosa simplex; Dermatology; Keratin; Epidermolysis bullosa; Chemistry; Trimethylamine N-oxide; Trimethylamine; Keratin 14; Medicine; Pathology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001036009,0.0002323352,0.0002878604,0.000158968,0.0001711559,0.0001681029,0.0001308229,0.000290901,0.001660061],"category_scores_gemma":[0.0001000498,0.0001110951,0.0003110271,0.0001222627,0.0001327286,0.0002227668,0.0001563603,0.0004201603,0.0003593253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001069358,"about_ca_system_score_gemma":0.0001455924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000620963,"about_ca_topic_score_gemma":0.0006365624,"domain_scores_codex":[0.9998969,0.00001627241,0.00001274002,0.0000218632,0.00002988617,0.00002229074],"domain_scores_gemma":[0.9999155,0.0000123218,0.00001429021,0.00001118353,0.00002221711,0.00002457283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002825508,0.00006422737,0.0001654571,0.00004720097,0.000006878067,0.00006794633,0.0000381611,0.00001273789,0.9982848,0.00001339772,0.00002370677,0.0009929843],"study_design_scores_gemma":[0.00002702428,0.001347323,0.009089019,0.00001316944,0.00003671494,0.0002895564,0.0001379113,0.0002692676,0.9869681,0.00003591605,0.001779714,0.00000621149],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940693,0.003149024,0.0008806452,0.00007307793,0.0001010306,0.00004316835,0.0001925376,0.00004093334,0.001450193],"genre_scores_gemma":[0.9935173,0.001707271,0.001588898,0.00006189549,0.00001691241,0.00006303578,0.000275792,0.00001400105,0.002754904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001660061,"threshold_uncertainty_score":0.005553424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01475050713073921,"score_gpt":0.2815283107239852,"score_spread":0.266777803593246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}