{"id":"W1913200510","doi":"10.1139/o11-035","title":"OxLDL-mediated survival of macrophages does not require LDL internalization or signalling by major pattern recognition receptors","year":2011,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Atherosclerosis and Cardiovascular Diseases","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stornoway Diamond (Canada); University of British Columbia; Vancouver Coastal Health","funders":"Heart and Stroke Foundation of British Columbia and Yukon; Heart and Stroke Foundation of Canada","keywords":"Scavenger receptor; CD36; Internalization; Receptor; Cell biology; Endocytic cycle; Macrophage; TLR4; Foam cell; Rage (emotion); Chemistry; TLR2; Signal transduction; CD14; Pattern recognition receptor; Biology; Innate immune system; Endocytosis; Biochemistry; Lipoprotein; Cholesterol; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002124694,0.000210511,0.0004010664,0.0001209974,0.0001220781,0.0003298227,0.0002061851,0.0003310378,0.001592349],"category_scores_gemma":[0.0001718328,0.0001153057,0.0002343625,0.0001016023,0.0002017709,0.0002605501,0.0003312006,0.0005085769,0.0006914839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000169222,"about_ca_system_score_gemma":0.0001983228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003348636,"about_ca_topic_score_gemma":0.0004613085,"domain_scores_codex":[0.9996754,0.00005331834,0.00003242692,0.00004591063,0.0001068441,0.00008605788],"domain_scores_gemma":[0.9997601,0.00003548913,0.0000543104,0.00004920941,0.00006307475,0.00003777978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004902531,0.00007281312,0.0004790239,0.00009861221,0.000009068089,0.0001351063,0.00004843637,0.00002852039,0.9956951,0.0001304352,0.00005192208,0.002760787],"study_design_scores_gemma":[0.00007712212,0.001359142,0.01843741,0.00004761526,0.00002667492,0.001153383,0.0001429907,0.0006930732,0.9676734,0.0001929064,0.01018405,0.00001216676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907249,0.00448725,0.001934347,0.0001654158,0.00005644634,0.00003899765,0.0003105127,0.00003901517,0.002243115],"genre_scores_gemma":[0.9905004,0.001795399,0.001517347,0.0001379476,0.00002505351,0.00006373572,0.0009978552,0.00001608886,0.004946228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001592349,"threshold_uncertainty_score":0.005326927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01833546721724284,"score_gpt":0.2097699770521373,"score_spread":0.1914345098348945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}