{"id":"W1913342407","doi":"10.1016/j.npep.2015.10.008","title":"Characterization of endoproteolytic processing of dynorphins by proprotein convertases using mouse spinal cord S9 fractions and mass spectrometry","year":2015,"lang":"en","type":"article","venue":"Neuropeptides","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Agència de Gestió d'Ajuts Universitaris i de Recerca; Natural Sciences and Engineering Research Council of Canada","keywords":"Dynorphin; Dynorphin A; Chemistry; Proprotein Convertases; Proteolysis; Opioid peptide; Neuropeptide; Endogeny; Spinal cord; Endogenous opioid; Central nervous system; Biochemistry; Endocrinology; Neuroscience; Opioid; Biology; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002292392,0.000719937,0.0002423966,0.00065231,0.0003230211,0.0004345458,0.0002687412,0.0002724724,0.001043615],"category_scores_gemma":[0.0002613308,0.0001630313,0.0005275438,0.0003543191,0.0002679806,0.0003484172,0.0001873975,0.0007178697,0.0005512914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004060882,"about_ca_system_score_gemma":0.0003104048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001930235,"about_ca_topic_score_gemma":0.001748741,"domain_scores_codex":[0.9998794,0.000008031034,0.0000116629,0.00003419215,0.00002830417,0.00003851064],"domain_scores_gemma":[0.9997544,0.00005011327,0.00007045986,0.0000197355,0.00005752856,0.00004773726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002054701,0.00002127076,0.0006524035,0.0000308103,0.0000130206,0.0001346452,0.00002375563,0.00003015703,0.9971855,0.0001036245,0.00005261752,0.001546629],"study_design_scores_gemma":[0.00001161684,0.0001246395,0.02288987,0.00001397863,0.00003949415,0.0005843504,0.00008463486,0.0007475185,0.9722648,0.0001314553,0.003096415,0.00001131209],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977232,0.003062107,0.01460198,0.0002367421,0.0000842923,0.00008242201,0.002590366,0.00009943832,0.002010558],"genre_scores_gemma":[0.9537485,0.004823666,0.02461045,0.0002938575,0.0000591162,0.0001224998,0.008457283,0.0001143736,0.00777033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001930235,"threshold_uncertainty_score":0.003838003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04239653385981595,"score_gpt":0.2909174827721859,"score_spread":0.2485209489123699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}