{"id":"W1914885525","doi":"10.1161/circresaha.114.305951","title":"Endothelial NO-Synthase Gene-Enhanced Progenitor Cell Therapy for Pulmonary Arterial Hypertension","year":2015,"lang":"en","type":"article","venue":"Circulation Research","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":147,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Ottawa; Jewish General Hospital; Northern Therapeutics (Canada); Ottawa Hospital; St. Michael's Hospital","funders":"Jewish General Hospital; University of Toronto; Ottawa Hospital Research Institute","keywords":"Medicine; Progenitor cell; Hemodynamics; Tolerability; Pulmonary hypertension; Endothelial dysfunction; Vascular resistance; Pulmonary artery; Endothelial progenitor cell; Endothelial stem cell; Cardiology; Nitric oxide synthase; Internal medicine; Adverse effect; Nitric oxide; Stem cell; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001740471,0.0001480331,0.0002225876,0.0001234753,0.00008228228,0.000171101,0.00012434,0.000167591,0.0006604059],"category_scores_gemma":[0.0001940253,0.00003484499,0.00009133787,0.00008123205,0.0001642393,0.00006287811,0.00009710846,0.0004160665,0.0001226967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001086413,"about_ca_system_score_gemma":0.0002266203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001009165,"about_ca_topic_score_gemma":0.0002036317,"domain_scores_codex":[0.9999546,0.00001509498,0.000003894216,0.000006320527,0.00001333922,0.000006712688],"domain_scores_gemma":[0.9999408,0.00001995598,0.00001465598,0.000003987813,0.000005785217,0.00001485566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00951604,0.003762166,0.01453425,0.0007513079,0.00009989161,0.001796384,0.0002419182,0.002856534,0.6148009,0.0009981482,0.001717707,0.3489246],"study_design_scores_gemma":[0.02394025,0.2041097,0.1090404,0.0003318779,0.000676461,0.01859896,0.0002115007,0.01766458,0.5696654,0.001085258,0.05461235,0.00006332056],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893523,0.006176408,0.002317535,0.0004061031,0.0000520633,0.000129784,0.00005739632,0.00003803572,0.001470484],"genre_scores_gemma":[0.9949434,0.002336562,0.00173683,0.0001406739,0.00006940996,0.0001017035,0.00009016999,0.000003001493,0.0005782644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006604059,"threshold_uncertainty_score":0.002209306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1631275725624602,"score_gpt":0.379697925506967,"score_spread":0.2165703529445069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}