{"id":"W1914885525","doi":"10.1161/circresaha.114.305951","title":"Endothelial NO-Synthase Gene-Enhanced Progenitor Cell Therapy for Pulmonary Arterial Hypertension","year":2015,"lang":"en","type":"article","venue":"Circulation Research","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":147,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Ottawa; Jewish General Hospital; Northern Therapeutics (Canada); Ottawa Hospital; St. Michael's Hospital","funders":"Jewish General Hospital; University of Toronto; Ottawa Hospital Research Institute","keywords":"Medicine; Progenitor cell; Hemodynamics; Tolerability; Pulmonary hypertension; Endothelial dysfunction; Vascular resistance; Pulmonary artery; Endothelial progenitor cell; Endothelial stem cell; Cardiology; Nitric oxide synthase; Internal medicine; Adverse effect; Nitric oxide; Stem cell; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009219837,0.0002059609,0.0003382897,0.0003501631,0.0002963168,0.00007065108,0.000157182,0.0001813322,0.000206591],"category_scores_gemma":[0.0006119409,0.0001637599,0.0001647733,0.0003686282,0.0001487506,0.0001859403,0.00006424419,0.0002818937,0.0008245633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001925677,"about_ca_system_score_gemma":0.0007108728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006726807,"about_ca_topic_score_gemma":0.000001258942,"domain_scores_codex":[0.9967276,0.0002575126,0.0003135739,0.000584313,0.001375534,0.0007414661],"domain_scores_gemma":[0.99607,0.0002404264,0.00005416672,0.0005389817,0.002353375,0.0007430082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00761208,0.00209014,0.003850262,0.00006031445,0.00007300463,0.0007264737,0.00005615384,0.00001954784,0.9696496,0.000007403707,0.005410892,0.01044411],"study_design_scores_gemma":[0.04980607,0.006880771,0.09157922,0.0002004319,0.0001146291,0.001074059,0.0005741654,0.0492163,0.7520079,0.001727822,0.0458609,0.000957752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917148,0.0006654251,0.0002716009,0.0007204243,0.0004235953,0.003149329,0.00007297219,0.00008958914,0.00289227],"genre_scores_gemma":[0.9945368,0.000155232,0.0009503854,0.0001503629,0.00122089,0.0006787423,0.0004060455,0.0000610125,0.001840558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2176417,"threshold_uncertainty_score":0.9999534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1631275725624602,"score_gpt":0.379697925506967,"score_spread":0.2165703529445069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}