{"id":"W1917209917","doi":"10.1111/j.1365-2265.2010.03868.x","title":"Physiological versus standard sex steroid replacement in young women with premature ovarian failure: effects on bone mass acquisition and turnover","year":2010,"lang":"en","type":"article","venue":"Clinical Endocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":147,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Ottawa Mental Health Centre","funders":"","keywords":"Medicine; Internal medicine; Endocrinology; Bone remodeling; Bone mineral; Bone resorption; N-terminal telopeptide; Hormone replacement therapy (female-to-male); Bone density; Femoral neck; Premature ovarian failure; Osteoporosis; Osteocalcin; Testosterone (patch); Alkaline phosphatase; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002537369,0.0002333471,0.0003823337,0.00004511227,0.00005700123,0.00001929136,0.0001237388,0.000550986,0.00002236931],"category_scores_gemma":[0.0001948433,0.000167571,0.00005760685,0.000065886,0.0002479858,0.000005597691,0.0001205785,0.0008608875,0.00001067271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002508116,"about_ca_system_score_gemma":0.00004160779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002706937,"about_ca_topic_score_gemma":0.00003732734,"domain_scores_codex":[0.9981821,0.0002495991,0.0003108223,0.0006461387,0.0001197167,0.0004916873],"domain_scores_gemma":[0.9991474,0.0001532603,0.0001097144,0.0004037118,0.00003296936,0.0001529397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0441158,0.0004343656,0.02604743,0.00007717319,0.0003952336,0.0003672328,0.0001087682,0.00002430218,0.9192436,0.000783719,0.00131368,0.007088659],"study_design_scores_gemma":[0.07556237,0.1254375,0.391039,0.0001950874,0.0002083761,0.0008292415,0.0003801093,0.000106392,0.3831468,0.001147023,0.02001765,0.001930428],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980567,0.0001422407,0.0000390799,0.0003835966,0.0005357635,0.0003886811,0.000008368468,0.00002622369,0.000419314],"genre_scores_gemma":[0.9985588,0.0001182901,0.0004804571,0.0002531303,0.0003286998,0.00007372205,0.00005008797,0.00002117976,0.0001156734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5360968,"threshold_uncertainty_score":0.6833349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007708668586772404,"score_gpt":0.2766951134489454,"score_spread":0.268986444862173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}