{"id":"W1917209917","doi":"10.1111/j.1365-2265.2010.03868.x","title":"Physiological versus standard sex steroid replacement in young women with premature ovarian failure: effects on bone mass acquisition and turnover","year":2010,"lang":"en","type":"article","venue":"Clinical Endocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":147,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Ottawa Mental Health Centre","funders":"","keywords":"Medicine; Internal medicine; Endocrinology; Bone remodeling; Bone mineral; Bone resorption; N-terminal telopeptide; Hormone replacement therapy (female-to-male); Bone density; Femoral neck; Premature ovarian failure; Osteoporosis; Osteocalcin; Testosterone (patch); Alkaline phosphatase; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001274821,0.0002778783,0.001228111,0.0002009028,0.0001615062,0.0002584488,0.0003349447,0.0005464455,0.002078104],"category_scores_gemma":[0.001907458,0.0002089451,0.0005842452,0.0001877405,0.0006029486,0.0002832011,0.0002090748,0.0006406683,0.0001503396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001960877,"about_ca_system_score_gemma":0.0005375184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002756092,"about_ca_topic_score_gemma":0.0007797193,"domain_scores_codex":[0.9995709,0.0002496591,0.0000573248,0.00004161096,0.00004565427,0.0000349093],"domain_scores_gemma":[0.998862,0.0005081224,0.0002888861,0.00005669976,0.00003695137,0.0002473853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9219413,0.007001822,0.007975198,0.001039761,0.000615534,0.0001101653,0.00009623659,0.0002560833,0.007481275,0.00006362392,0.0001592285,0.05325972],"study_design_scores_gemma":[0.2528677,0.7134959,0.03011876,0.00009539063,0.0005444987,0.0002423837,0.00009438393,0.000295338,0.001387845,0.0001328107,0.0007097086,0.00001533153],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963381,0.003033855,0.00007883343,0.00007494634,0.00005469904,0.0001803418,0.00006937421,0.000006337438,0.0001634056],"genre_scores_gemma":[0.9972242,0.001477283,0.0004087445,0.0001467557,0.0001388635,0.0002884298,0.0001030418,0.000001470764,0.0002112779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002078104,"threshold_uncertainty_score":0.006951988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007708668586772404,"score_gpt":0.2766951134489454,"score_spread":0.268986444862173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}