{"id":"W1918288470","doi":"10.1016/j.nbt.2015.08.002","title":"Alterations in the phosphoproteomic profile of cells expressing a non-functional form of the SHP2 phosphatase","year":2015,"lang":"en","type":"article","venue":"New Biotechnology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Cancer Research; Biotechnology and Biological Sciences Research Council; Associazione Italiana per la Ricerca sul Cancro; Wellcome Trust; Wellcome","keywords":"Phosphorylation; Protein tyrosine phosphatase; Cell biology; Phosphatase; Biology; Signal transduction; MAPK/ERK pathway; Tyrosine phosphorylation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008459433,0.0002834282,0.0002494282,0.0001862876,0.000152136,0.0003905839,0.0001629165,0.0002606507,0.001502479],"category_scores_gemma":[0.0001163946,0.0001156143,0.0002133987,0.0003015955,0.0002028283,0.0002295927,0.0001958027,0.0005524171,0.000326593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001468074,"about_ca_system_score_gemma":0.0001409801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007048666,"about_ca_topic_score_gemma":0.000548798,"domain_scores_codex":[0.999921,0.000005753724,0.0000054579,0.00001621385,0.00002931365,0.00002223682],"domain_scores_gemma":[0.9999133,0.00001627659,0.00001669318,0.00001045685,0.00001452411,0.000028675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001205209,0.000007909823,0.0002321843,0.00000918035,0.000004851445,0.00003975623,0.000008672837,0.00001357537,0.9991829,0.00003478198,0.00001902581,0.0003266111],"study_design_scores_gemma":[0.0000128604,0.0001860156,0.0337703,0.000002703875,0.0000252672,0.0003643545,0.000103578,0.0007528729,0.9635791,0.00008913637,0.001106142,0.000007655359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956144,0.0004285448,0.001620263,0.0001062921,0.00004095648,0.000007759617,0.001184981,0.00003207897,0.0009647431],"genre_scores_gemma":[0.9936287,0.0004348986,0.001002944,0.00006760595,0.00000965788,0.00002441623,0.001938354,0.00001847345,0.002874893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001502479,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01505210851603769,"score_gpt":0.2351934288001162,"score_spread":0.2201413202840785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}