{"id":"W1920015155","doi":"10.1111/pme.12884","title":"Correlation of Subjective Effects with Systemic Opioid Exposure from Fixed-Dose Combinations of Oxycodone/Acetaminophen in Recreational Users of Prescription Drugs","year":2015,"lang":"en","type":"article","venue":"Pain Medicine","topic":"Opioid Use Disorder Treatment","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Mallinckrodt Pharmaceuticals","keywords":"Oxycodone; Acetaminophen; Cmax; Pharmacokinetics; Medicine; Pharmacology; Anesthesia; Pharmacodynamics; Crossover study; Opioid; Immediate release; Placebo; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005919021,0.0002394667,0.0002549775,0.0001971331,0.0001071128,0.0001929996,0.0001035722,0.00018368,0.001699395],"category_scores_gemma":[0.004601475,0.000154131,0.0002517721,0.0001381136,0.0001953934,0.0001663836,0.0001596538,0.0002356898,0.0001065234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001202338,"about_ca_system_score_gemma":0.00008055999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004237542,"about_ca_topic_score_gemma":0.0006252272,"domain_scores_codex":[0.9993804,0.0002719583,0.00005839738,0.00006074382,0.0001896136,0.00003891559],"domain_scores_gemma":[0.9959099,0.001491104,0.001924317,0.0001748248,0.0002325911,0.0002672487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01429997,0.0009336015,0.9396027,0.0002374493,0.0005298748,0.0001665629,0.0001986174,0.0002207042,0.01809337,0.00002187392,0.0001071245,0.02558814],"study_design_scores_gemma":[0.00007885647,0.003124599,0.9956613,0.000003980164,0.00004398645,0.0002193257,0.00005149972,0.000169188,0.0005722382,0.000004318315,0.00006704158,0.000003616027],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993809,0.0002575328,0.00009794044,0.000007285784,0.000002912903,0.00001856281,0.00006238548,0.000001879801,0.0001706415],"genre_scores_gemma":[0.9996044,0.00009133724,0.0001294812,0.00001035495,0.000006359506,0.00001157309,0.00006523111,7.315834e-7,0.00008052446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001699395,"threshold_uncertainty_score":0.005685031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01145744564790742,"score_gpt":0.2454218151621601,"score_spread":0.2339643695142527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}