{"id":"W1920228500","doi":"10.1136/annrheumdis-2015-207653","title":"Efficacy and safety of subcutaneous tabalumab in patients with systemic lupus erythematosus: results from ILLUMINATE-1, a 52-week, phase III, multicentre, randomised, double-blind, placebo-controlled study","year":2015,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":234,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital; University of Toronto","funders":"Santen; Eli Lilly and Company","keywords":"Medicine; Placebo; Double blind; Systemic reaction; Lupus erythematosus; Systemic disease; Internal medicine; Dermatology; Clinical trial; Surgery; Physical therapy; Immunology; Immunopathology; Alternative medicine; Antibody; Pathology; Allergy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001440297,0.001034839,0.003108682,0.0003703914,0.0002638836,0.0008795509,0.0007890527,0.001436079,0.002638118],"category_scores_gemma":[0.001500396,0.000546144,0.00152391,0.0003614536,0.0009296493,0.0009170753,0.0002448602,0.002321534,0.0006516994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003814966,"about_ca_system_score_gemma":0.000410514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004071023,"about_ca_topic_score_gemma":0.0005971896,"domain_scores_codex":[0.9995238,0.0002420521,0.00003671218,0.00006938026,0.00005725888,0.00007078996],"domain_scores_gemma":[0.9990557,0.0003177003,0.0002519098,0.0000729678,0.00005112164,0.0002507078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9162133,0.007392782,0.00239055,0.001751586,0.002090132,0.0001002903,0.0001108946,0.0006096503,0.01620822,0.00008821351,0.0009182075,0.05212626],"study_design_scores_gemma":[0.883591,0.1023357,0.01004734,0.00006294597,0.001111935,0.0001315006,0.0000436113,0.0006701477,0.001229354,0.00009950076,0.000645225,0.00003179762],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852544,0.01180886,0.0004801212,0.000348399,0.0001751259,0.0003679569,0.0004172901,0.0001229973,0.001024794],"genre_scores_gemma":[0.9936871,0.00326932,0.0005161652,0.0006463402,0.0002633155,0.0003122807,0.0005491469,0.00002268514,0.000733733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003108682,"threshold_uncertainty_score":0.008825421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04464483908085513,"score_gpt":0.3185217653247155,"score_spread":0.2738769262438603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}