{"id":"W1920228500","doi":"10.1136/annrheumdis-2015-207653","title":"Efficacy and safety of subcutaneous tabalumab in patients with systemic lupus erythematosus: results from ILLUMINATE-1, a 52-week, phase III, multicentre, randomised, double-blind, placebo-controlled study","year":2015,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":234,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital; University of Toronto","funders":"Santen; Eli Lilly and Company","keywords":"Medicine; Placebo; Double blind; Systemic reaction; Lupus erythematosus; Systemic disease; Internal medicine; Dermatology; Clinical trial; Surgery; Physical therapy; Immunology; Immunopathology; Alternative medicine; Antibody; Pathology; Allergy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001542388,0.0004736755,0.002451767,0.0003406095,0.00008071721,0.00003918494,0.0004870764,0.0001109299,0.00002877726],"category_scores_gemma":[0.003407502,0.0002751981,0.0002619613,0.0005091059,0.0003234644,0.0001571752,0.0002334726,0.0002125526,0.000008364146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001071408,"about_ca_system_score_gemma":0.0004463888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006817121,"about_ca_topic_score_gemma":0.00006914978,"domain_scores_codex":[0.9941149,0.0007856769,0.002235343,0.0005922165,0.001728377,0.0005434963],"domain_scores_gemma":[0.9934834,0.002468354,0.00132532,0.00134462,0.0008647515,0.0005136046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8890955,0.009927722,0.08482693,0.001069965,0.001628199,0.00007976608,0.01208576,0.0001304816,0.000009452871,0.000005748252,0.0003403551,0.0008000982],"study_design_scores_gemma":[0.968195,0.002321746,0.002706027,0.009279278,0.001024982,0.0004089316,0.01435216,0.001340002,0.00006687215,0.00002475547,0.000002561851,0.0002777116],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808536,0.002183974,0.000008130163,0.0001251314,0.0001817575,0.0161109,0.0003036775,0.00004265118,0.0001902154],"genre_scores_gemma":[0.9990155,0.0001521785,0.00003164119,0.00001737383,0.0000222159,0.0003076478,0.00008425557,0.00005933985,0.0003098751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0821209,"threshold_uncertainty_score":0.99997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04464483908085513,"score_gpt":0.3185217653247155,"score_spread":0.2738769262438603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}