{"id":"W1920459206","doi":"10.1007/s12263-015-0486-y","title":"Multiple effects of curcumin on promoting expression of the exon 7-containing SMN2 transcript","year":2015,"lang":"en","type":"article","venue":"Genes & Nutrition","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"SMN1; Exon; Curcumin; RNA splicing; Spinal muscular atrophy; Alternative splicing; Biology; Molecular biology; SMA*; Cell biology; Chemistry; Gene; RNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001142599,0.000461811,0.0003937641,0.0002878244,0.0002285915,0.0001896029,0.0001244487,0.0002795263,0.002581166],"category_scores_gemma":[0.000145184,0.000191734,0.0005454505,0.000129543,0.0002505463,0.0002766143,0.0002130471,0.0006180466,0.000325295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002844515,"about_ca_system_score_gemma":0.0002769394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009409187,"about_ca_topic_score_gemma":0.003361291,"domain_scores_codex":[0.9999002,0.00001470615,0.000009559013,0.00002944333,0.0000167022,0.0000293773],"domain_scores_gemma":[0.9998814,0.00002862359,0.00002001531,0.00001620405,0.00002087937,0.00003291509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001710923,0.00005967396,0.000182878,0.0001276936,0.00001859062,0.00005230856,0.00001677731,0.0000337156,0.995735,0.00003905785,0.00009395744,0.001929205],"study_design_scores_gemma":[0.00006473944,0.0008072763,0.008393805,0.00001891505,0.0001088029,0.0001294121,0.00007218633,0.0002066679,0.9881073,0.00005911944,0.002022135,0.0000095367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892117,0.004959656,0.001670559,0.0002977351,0.0001635672,0.00005133318,0.0008054498,0.0001117623,0.002728234],"genre_scores_gemma":[0.9879309,0.002651291,0.002262075,0.0001062195,0.0000276265,0.00008756254,0.0007181618,0.00003676001,0.006179389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002581166,"threshold_uncertainty_score":0.008634925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03284058819215151,"score_gpt":0.2863619770784162,"score_spread":0.2535213888862647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}