{"id":"W1920584780","doi":"10.1210/me.2015-1091","title":"Minireview: Role of Intracellular Scaffolding Proteins in the Regulation of Endocrine G Protein-Coupled Receptor Signaling","year":2015,"lang":"en","type":"review","venue":"Molecular Endocrinology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"G protein-coupled receptor; Biology; Heterotrimeric G protein; Scaffold protein; Signal transduction; Cell biology; G protein; Intracellular; Receptor; Cell signaling; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000865354,0.0005722771,0.001799954,0.0003077992,0.00004476909,0.0000171607,0.0008741754,0.0004249182,0.00008849421],"category_scores_gemma":[0.0002624629,0.0004443878,0.0006259692,0.0004568097,0.0001497971,0.000007284998,0.0002577218,0.0003727335,0.000008927792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005213837,"about_ca_system_score_gemma":0.000342597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004842591,"about_ca_topic_score_gemma":0.000005708312,"domain_scores_codex":[0.9958256,0.0009737415,0.001456321,0.0007239628,0.0004226798,0.0005976342],"domain_scores_gemma":[0.9975896,0.00004195199,0.001091282,0.0009574224,0.000246183,0.00007348656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002966969,0.0001121567,0.000001417797,0.002925528,0.0001582393,0.00001750756,0.00005693135,0.00004241199,0.840289,0.001462709,0.00002181486,0.1548826],"study_design_scores_gemma":[0.000387953,0.0004203228,2.404936e-7,0.00224289,0.0002243485,0.00008778948,0.00009059066,0.00002319589,0.5151013,0.0002987169,0.480772,0.000350603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02047301,0.9754773,0.0009376297,0.00002129534,0.0001092984,0.002801283,0.00002638497,0.00001166571,0.0001420724],"genre_scores_gemma":[0.0345158,0.9595754,0.003992001,0.00002285776,0.0002147742,0.000858239,0.0006047864,0.0001323533,0.00008383267],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4807502,"threshold_uncertainty_score":0.9998008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02184527714937436,"score_gpt":0.2813752224027646,"score_spread":0.2595299452533902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}