{"id":"W1920785403","doi":"10.1089/humc.2014.145","title":"A Multicenter, Single-Blind, Phase IIa Clinical Trial to Evaluate the Efficacy and Safety of a Cell-Mediated Gene Therapy in Degenerative Knee Arthritis Patients","year":2015,"lang":"en","type":"article","venue":"Human Gene Therapy Clinical Development","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Osteoarthritis; WOMAC; Medicine; Cartilage; Adverse effect; Visual analogue scale; Clinical endpoint; Internal medicine; Randomized controlled trial; Arthritis; Surgery; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003252028,0.0004544728,0.001208262,0.0001779881,0.0001587294,0.00003794208,0.0002149295,0.0002812196,0.00009326458],"category_scores_gemma":[0.0004667412,0.0003122914,0.0002335113,0.0002802879,0.000226759,0.00006719208,0.0001316848,0.0003800367,0.00004995203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001350126,"about_ca_system_score_gemma":0.0005676504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001039242,"about_ca_topic_score_gemma":0.00008353279,"domain_scores_codex":[0.9942656,0.0009968211,0.002694365,0.0007990064,0.0007362526,0.0005080035],"domain_scores_gemma":[0.9973997,0.0005987415,0.000394766,0.0005352743,0.0004366648,0.0006348672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3214864,0.0230577,0.01194458,0.000007647312,0.000421278,0.00007114751,0.005310006,0.000002523809,0.0165757,0.000009954078,0.0002294874,0.6208836],"study_design_scores_gemma":[0.8481233,0.06844759,0.03004294,0.0001885636,0.00006863921,0.000004541147,0.0001486336,0.00001908833,0.04712236,0.00004042666,0.005350797,0.0004431323],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911048,0.001577885,0.00005165526,0.0002837526,0.0008330552,0.005995876,0.0000242358,0.000044501,0.00008423011],"genre_scores_gemma":[0.9903979,0.002351749,0.004520865,0.001452482,0.0003990121,0.0003439616,0.0003212472,0.00006360668,0.0001492072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6204404,"threshold_uncertainty_score":0.9999329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.196832391785746,"score_gpt":0.416537915641443,"score_spread":0.219705523855697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}