{"id":"W1921303390","doi":"10.4049/jimmunol.1401644","title":"OX40- and CD27-Mediated Costimulation Synergizes with Anti–PD-L1 Blockade by Forcing Exhausted CD8+ T Cells To Exit Quiescence","year":2014,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; Cancer Research UK","keywords":"Cytotoxic T cell; CD8; Blockade; T cell; Effector; Cytokine; Cell biology; Biology; IL-2 receptor; Immunology; Memory T cell; PD-L1; Population; Immune system; Cancer research; Immunotherapy; Receptor; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002044856,0.0006531295,0.0003878361,0.0002941498,0.0001330631,0.0003744387,0.0003423922,0.0003151033,0.001218508],"category_scores_gemma":[0.000139107,0.0001867633,0.0003570906,0.0001615276,0.0002945134,0.0002354025,0.0002852665,0.001072146,0.0003785481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003749089,"about_ca_system_score_gemma":0.0006044437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005676784,"about_ca_topic_score_gemma":0.001346998,"domain_scores_codex":[0.9997386,0.00004764678,0.00002502776,0.00002402271,0.00004548026,0.0001191807],"domain_scores_gemma":[0.9997986,0.00004470693,0.00003850333,0.00001959345,0.00001023392,0.00008842438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00213967,0.00126036,0.0005051397,0.0001473366,0.00003680932,0.0001398563,0.00005998654,0.001109561,0.9845776,0.0003296055,0.0003008142,0.009393192],"study_design_scores_gemma":[0.000395785,0.009477621,0.004562151,0.00001745674,0.000073807,0.0003455409,0.00004566739,0.002575839,0.9786078,0.0001081401,0.003777097,0.00001300115],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971673,0.0006939673,0.0004613233,0.00008131302,0.00003646969,0.00004416159,0.0001142007,0.00006988627,0.001331398],"genre_scores_gemma":[0.9961746,0.0006679954,0.000753427,0.00007162315,0.00004187789,0.00006859782,0.0002931342,0.00001487494,0.001913879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001218508,"threshold_uncertainty_score":0.004076302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005603738439699622,"score_gpt":0.2026195005121227,"score_spread":0.1970157620724231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}