{"id":"W1921456558","doi":"10.1172/jci81261","title":"Inflammatory IL-15 is required for optimal memory T cell responses","year":2015,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Holden Comprehensive Cancer Center, University of Iowa; National Center for Research Resources; American Heart Association; Roy J. and Lucille A. Carver College of Medicine, University of Iowa; National Cancer Institute; National Institutes of Health; McGill University","keywords":"Cytotoxic T cell; CD8; Biology; Memory T cell; T cell; Immunology; mTORC1; CD28; Antigen; Memory cell; Cell biology; Immune system; PI3K/AKT/mTOR pathway; Signal transduction; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000217922,0.0003190372,0.0003916105,0.0001910238,0.0001825072,0.0005446676,0.0001510382,0.0003166322,0.001593428],"category_scores_gemma":[0.0003522284,0.0001470029,0.0002093966,0.0001039964,0.0002583737,0.0002508187,0.0002529793,0.0006194117,0.0004470541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003358038,"about_ca_system_score_gemma":0.0004399656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002243462,"about_ca_topic_score_gemma":0.0004569216,"domain_scores_codex":[0.9997292,0.00005982135,0.0000409332,0.00004203342,0.00004143515,0.00008657513],"domain_scores_gemma":[0.9998228,0.00002154732,0.0000525268,0.00001688279,0.00001629954,0.00006989684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006413526,0.00008001535,0.001913323,0.00013339,0.00001062449,0.0001726026,0.00003307534,0.0001376319,0.9903635,0.000200795,0.0001216012,0.006192151],"study_design_scores_gemma":[0.0001952479,0.002553752,0.04706705,0.0001073668,0.00007905206,0.001962356,0.0001478852,0.001675894,0.9343633,0.0005803084,0.01125372,0.00001403255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895445,0.005917546,0.001905198,0.0002306997,0.00007718185,0.00005823214,0.0002567813,0.0001174196,0.00189247],"genre_scores_gemma":[0.9973378,0.0006269707,0.00116695,0.0000626719,0.00002392775,0.00003258381,0.0001821286,0.000009067374,0.0005579305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001593428,"threshold_uncertainty_score":0.005330563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1165947611579051,"score_gpt":0.3643724071889946,"score_spread":0.2477776460310894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}