{"id":"W1921965655","doi":"10.1111/jnc.13378","title":"Proteolytic degradation of neuropeptide Y (<scp>NPY</scp>) from head to toe: Identification of novel<scp>NPY</scp>‐cleaving peptidases and potential drug interactions in<scp>CNS</scp>and Periphery","year":2015,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's & Women's Health Centre of British Columbia; University of British Columbia","funders":"Life Technologies Corporation","keywords":"Neuropeptide Y receptor; Neprilysin; Endopeptidase; Dipeptidyl peptidase; Cathepsin; Receptor; Cathepsin D; Biochemistry; Signal transduction; Enzyme; Chemistry; Biology; Cell biology; Neuropeptide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001010949,0.00039542,0.0002630331,0.0001993106,0.00007193266,0.0001984273,0.00009622658,0.0002316078,0.0005079267],"category_scores_gemma":[0.0001285537,0.00008771821,0.0002453466,0.0001362518,0.0001825695,0.0001843884,0.0001180019,0.0002330205,0.0002061129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002185569,"about_ca_system_score_gemma":0.0001789865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005959893,"about_ca_topic_score_gemma":0.0005863075,"domain_scores_codex":[0.9999493,0.000007415872,0.000004253775,0.00001519243,0.00001066368,0.00001310522],"domain_scores_gemma":[0.9999448,0.00000861092,0.00001735651,0.000003351221,0.000008099377,0.00001767898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003156374,0.00001110394,0.0006661551,0.00007312268,0.0000101878,0.0002322939,0.000009327534,0.00004799689,0.9944789,0.00002531913,0.00002658521,0.004103338],"study_design_scores_gemma":[0.00003342066,0.0007247888,0.03515367,0.00001440714,0.00004484376,0.003112666,0.00004970298,0.001382492,0.956803,0.000079991,0.0025902,0.00001077599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851655,0.009928149,0.00370498,0.00006543424,0.00001601417,0.00004363972,0.0003757403,0.00002590751,0.0006746831],"genre_scores_gemma":[0.987541,0.005215071,0.00461371,0.00006269211,0.0000151696,0.000042647,0.0008189746,0.00001019778,0.001680438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005959893,"threshold_uncertainty_score":0.00169915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04013523187583647,"score_gpt":0.2851589967387574,"score_spread":0.2450237648629209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}