{"id":"W1923182887","doi":"10.1186/1471-2350-7-71","title":"Genome-wide significance for a modifier of age at neurological onset in Huntington's Disease at 6q23-24: the HD MAPS study","year":2006,"lang":"en","type":"article","venue":"BMC Medical Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of British Columbia","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Pedigree chart; Biology; Genetics; Genome Scan; Quantitative trait locus; Linkage (software); Genetic linkage; Microsatellite; Human genetics; Allele; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005290017,0.0003291231,0.0004055385,0.00008769342,0.0002305575,0.00003463637,0.0009667057,0.0001029511,0.0001620766],"category_scores_gemma":[0.005149957,0.0002403599,0.0001907898,0.0003583069,0.0007487948,0.00002454509,0.0006052301,0.000222824,0.00002871392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004948441,"about_ca_system_score_gemma":0.0002878029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001844901,"about_ca_topic_score_gemma":0.0006432554,"domain_scores_codex":[0.9952735,0.001003372,0.0007676362,0.0009861565,0.001320786,0.0006485752],"domain_scores_gemma":[0.9955726,0.002927474,0.0002261222,0.000802524,0.00006366682,0.0004075941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009462833,0.002336873,0.8972842,0.0001331395,0.000007447839,0.0002209178,0.0001872984,0.01147774,0.08512083,0.0001800573,0.001901778,0.0002034636],"study_design_scores_gemma":[0.001783698,0.0004886907,0.9356989,0.00001281464,0.00006486824,0.000003644817,0.00003106644,0.003275674,0.05505918,0.0007642015,0.002509774,0.0003075109],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959965,0.0002367979,0.0005424176,0.000551425,0.0002680638,0.002032274,0.0002250675,0.0000390081,0.0001084276],"genre_scores_gemma":[0.9964909,0.00007056828,0.0003218419,0.001666527,0.0001689131,0.0004197311,0.0000265839,0.00004635802,0.0007885981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0384147,"threshold_uncertainty_score":0.9801591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04916127282059388,"score_gpt":0.2837990846260579,"score_spread":0.234637811805464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}