{"id":"W1924457352","doi":"10.1111/j.1468-3083.2012.04705.x","title":"Safety results from a pooled analysis of randomized, controlled phase II and III clinical trials and interim data from an open‐label extension trial of the interleukin‐12/23 monoclonal antibody, briakinumab, in moderate to severe psoriasis","year":2012,"lang":"en","type":"article","venue":"Journal of the European Academy of Dermatology and Venereology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; Dalhousie University","funders":"","keywords":"Medicine; Mace; Adverse effect; Internal medicine; Interim analysis; Clinical trial; Incidence (geometry); Population; Surgery; Myocardial infarction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.08219039,0.003236728,0.00923821,0.002962488,0.0005283298,0.002710325,0.001226605,0.00209176,0.003547159],"category_scores_gemma":[0.07569802,0.001390696,0.02712172,0.002322196,0.001276901,0.002068331,0.001388069,0.002269173,0.0004857252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009002202,"about_ca_system_score_gemma":0.001362826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003030211,"about_ca_topic_score_gemma":0.0004650539,"domain_scores_codex":[0.9355323,0.04508773,0.008623056,0.005216146,0.004705816,0.0008349877],"domain_scores_gemma":[0.9204361,0.04346647,0.02243588,0.007638291,0.004857764,0.001165484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.471785,0.0007658589,0.02307856,0.01042115,0.4536335,0.0001300756,0.0001429023,0.002877033,0.002207954,0.0001856317,0.001889759,0.03288256],"study_design_scores_gemma":[0.2042042,0.0430924,0.08649094,0.001230369,0.653002,0.0005292227,0.0001264307,0.003413658,0.002504282,0.001261355,0.003945812,0.0001992752],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7020846,0.2306624,0.03113879,0.001036156,0.001442753,0.009527864,0.01739592,0.00103352,0.005678073],"genre_scores_gemma":[0.9719262,0.01017634,0.005083689,0.0007272665,0.0005013724,0.003686878,0.007207799,0.0001262467,0.0005643051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08219039,"threshold_uncertainty_score":0.4346695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1295731250105945,"score_gpt":0.414242384369461,"score_spread":0.2846692593588664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}