{"id":"W1925308079","doi":"10.21037/1123","title":"Targeting ataxia-telangiectasia mutated deficient malignancies with poly ADP ribose polymerase inhibitors","year":2013,"lang":"en","type":"article","venue":"Translational Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Ataxia-telangiectasia; Poly ADP ribose polymerase; Cancer research; Polymerase; DNA repair; DNA damage; Mutation; DNA; Biology; Gene; Molecular biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005454814,0.0002423187,0.0002915455,0.0004254731,0.0003586271,0.00008299797,0.000156076,0.0001154511,0.005289196],"category_scores_gemma":[0.00003536771,0.0001955754,0.00009301953,0.001100843,0.0004161058,0.000290667,0.00002161282,0.0006019105,0.0003001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003072177,"about_ca_system_score_gemma":0.001001488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002753473,"about_ca_topic_score_gemma":0.00008141771,"domain_scores_codex":[0.9962836,0.0001735583,0.0004155934,0.0005143424,0.001821604,0.0007912997],"domain_scores_gemma":[0.9982011,0.0002149411,0.00007541607,0.0002842871,0.0008953811,0.0003289191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005008356,0.0008435182,0.08995651,0.0005837166,0.0005738215,0.0002599839,0.005461455,0.001993255,0.8095843,0.001822227,0.06292299,0.02098988],"study_design_scores_gemma":[0.02276468,0.002562724,0.1773425,0.002659383,0.0002006746,0.0004132772,0.002790145,0.005223075,0.7235435,0.002123792,0.05844247,0.001933768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9647336,0.01334306,0.0007921564,0.01608629,0.000174912,0.001696973,0.0002084136,0.0001787484,0.002785838],"genre_scores_gemma":[0.9952772,0.0001721401,0.001128065,0.000465007,0.0006623917,0.0008600588,0.0002335768,0.00007035669,0.001131201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08738601,"threshold_uncertainty_score":0.9956201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06194304950215909,"score_gpt":0.3793730274704367,"score_spread":0.3174299779682777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}