{"id":"W1925825565","doi":"10.1016/j.ajhg.2015.05.022","title":"Points to Consider: Ethical, Legal, and Psychosocial Implications of Genetic Testing in Children and Adolescents","year":2015,"lang":"en","type":"review","venue":"The American Journal of Human Genetics","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":898,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"National Center for Advancing Translational Sciences; National Human Genome Research Institute","keywords":"Psychosocial; Genetic testing; Medical genetics; Statement (logic); Engineering ethics; Test (biology); Medicine; Psychology; Political science; Genetics; Psychiatry; Biology; Law; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002390308,0.0006026467,0.001096663,0.00190752,0.0006063759,0.00161539,0.001187548,0.003431864,0.004103958],"category_scores_gemma":[0.006336717,0.0002200742,0.0005651854,0.001693367,0.001347804,0.001918175,0.001116477,0.004605234,0.0009038334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001535725,"about_ca_system_score_gemma":0.003127959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002879186,"about_ca_topic_score_gemma":0.008811321,"domain_scores_codex":[0.9993963,0.000182504,0.00007042434,0.00007080537,0.0002328195,0.00004710038],"domain_scores_gemma":[0.9965194,0.002454697,0.0002352849,0.00004283246,0.0005530933,0.0001945397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003197577,0.00002463722,0.0005334741,0.005749665,0.00006401985,0.0004803454,0.0002038256,0.0002230148,0.0001512428,0.009995035,0.1603734,0.8221694],"study_design_scores_gemma":[0.00001504925,0.0000202897,0.00129883,0.01577098,0.0001072714,0.002352093,0.0003581651,0.00007008194,0.00007865582,0.00771258,0.9721856,0.00003050869],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007310224,0.991026,0.0001125617,0.006417767,0.001249354,0.000002646955,0.00001354853,0.000004065182,0.001100982],"genre_scores_gemma":[0.001279196,0.9926512,0.0003129333,0.003250746,0.001672805,0.000007081702,0.00002463788,0.000002324321,0.000799021],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004103958,"threshold_uncertainty_score":0.0137291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0426088248687867,"score_gpt":0.3854298743079599,"score_spread":0.3428210494391732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}