{"id":"W1926182559","doi":"10.1371/journal.pone.0134000","title":"Variations in the FRA10AC1 Fragile Site and 15q21 Are Associated with Cerebrospinal Fluid Aβ1-42 Level","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; Servier; Eisai; Northern California Institute for Research and Education; University of California, San Diego; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Synarc; University of Southern California; Medpace; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Genome-wide association study; Alzheimer's Disease Neuroimaging Initiative; Biomarker; Cerebrospinal fluid; Biology; Locus (genetics); Genetics; Disease; Alzheimer's disease; Medicine; Internal medicine; Single-nucleotide polymorphism; Genotype; Gene; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001419338,0.0001026105,0.0000998221,0.00002433063,0.00007250202,0.00002954944,0.0001045771,0.00007157759,0.000007178759],"category_scores_gemma":[0.0001299733,0.0000798927,0.00001359037,0.0001074314,0.00004115371,0.00000302972,0.00005831401,0.00009349642,0.000006750999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001010653,"about_ca_system_score_gemma":0.00005311688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002935596,"about_ca_topic_score_gemma":0.0004250057,"domain_scores_codex":[0.999277,0.00006343922,0.000105542,0.0002089738,0.0001859224,0.0001591104],"domain_scores_gemma":[0.9996475,0.00001188857,0.00005019849,0.0001601852,0.00007552069,0.00005470206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001161762,0.001997582,0.4689336,0.0000299415,0.000260625,0.00001121706,0.001411635,0.00005946551,0.5243407,0.00006863849,0.002616104,0.0001543488],"study_design_scores_gemma":[0.001159506,0.0004332399,0.978681,0.00004829567,0.00004414436,0.000003033046,0.0003985711,0.000156084,0.01834451,0.0001136086,0.0004126532,0.000205327],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983352,0.0002356578,0.00009149825,0.000491719,0.00001307048,0.0001696259,0.00005035605,0.000005707351,0.0006071338],"genre_scores_gemma":[0.9982027,0.00007115001,0.0006615167,0.0006039678,0.00001511964,0.00002855676,0.0001428418,0.0000140396,0.0002600496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5097474,"threshold_uncertainty_score":0.325793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05180276112014497,"score_gpt":0.2167205957360103,"score_spread":0.1649178346158653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}