{"id":"W1926206592","doi":"10.1016/j.jsb.2015.08.014","title":"X-ray structural and molecular dynamical studies of the globular domains of cow, deer, elk and Syrian hamster prion proteins","year":2015,"lang":"en","type":"article","venue":"Journal of Structural Biology","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"PrioNet Canada; Compute Canada; University of Alberta; Canadian Light Source","keywords":"Biology; Bovine spongiform encephalopathy; Hamster; Prion protein; Prion Proteins; Transmissible spongiform encephalopathy; Scrapie; Infectivity; Strain (injury); Mesocricetus; Fungal prion; Genetics; Virology; Phenotype; Disease; Gene; Virus; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002286634,0.0001512675,0.0003409197,0.0000420009,0.00005046533,0.000009205678,0.0001984353,0.0001458636,0.000003070812],"category_scores_gemma":[0.000291322,0.0000881912,0.0001133798,0.00005868237,0.0004617044,0.000009702688,0.0002438148,0.0001251558,4.449194e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001759092,"about_ca_system_score_gemma":0.00007845047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001080223,"about_ca_topic_score_gemma":0.00000923837,"domain_scores_codex":[0.9989478,0.0001726254,0.0004244605,0.000162017,0.0001322556,0.0001608616],"domain_scores_gemma":[0.9989578,0.00001871811,0.0004685638,0.0001716733,0.0002739034,0.0001094059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003514592,0.000005803762,0.03455088,0.00006342198,0.0002511556,0.000005339644,0.0001378418,0.00004014108,0.9585089,0.0005121366,0.00001950474,0.00555342],"study_design_scores_gemma":[0.0073244,0.005361313,0.2342347,0.0003435879,0.0004951331,0.001411344,0.001644723,0.0003372977,0.716545,0.02900658,0.00255096,0.0007448642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9700086,0.02907484,0.000123468,0.000368118,0.0001993898,0.000192306,0.00002673961,0.000001391461,0.000005132191],"genre_scores_gemma":[0.9972804,0.0006138107,0.001915423,0.00007946011,0.00009254206,0.00000148809,0.000005114489,0.000008029429,0.000003799518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2419638,"threshold_uncertainty_score":0.3596333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01356310040802654,"score_gpt":0.2892060939292504,"score_spread":0.2756429935212238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}