{"id":"W1926467922","doi":"10.1002/bdd.1856","title":"Comparative effects of 1α‐hydroxyvitamin D<sub>3</sub> and 1,25‐dihydroxyvitamin D<sub>3</sub> on transporters and enzymes in <i>fxr(+/+)</i> and <i>fxr(‐/‐)</i> mice","year":2013,"lang":"en","type":"article","venue":"Biopharmaceutics & Drug Disposition","topic":"Vitamin D Research Studies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Calcitriol receptor; Farnesoid X receptor; Cholesterol 7 alpha-hydroxylase; Internal medicine; Endocrinology; CYP24A1; Bile acid; TRPV6; Chemistry; Vitamin D and neurology; Enterohepatic circulation; Receptor; Nuclear receptor; Biology; Medicine; Biochemistry; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004443487,0.0006280213,0.00106464,0.0005343291,0.0002114629,0.00007238023,0.0001318268,0.0002115528,0.000002847318],"category_scores_gemma":[0.00006484528,0.0005756434,0.0001352806,0.000510542,0.0009023352,0.000288584,0.0001318717,0.0006473683,0.00001679457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001463294,"about_ca_system_score_gemma":0.00005969112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007095278,"about_ca_topic_score_gemma":0.00005803404,"domain_scores_codex":[0.9967478,0.0002989997,0.0006913309,0.0008458488,0.0006593055,0.0007567344],"domain_scores_gemma":[0.99805,0.0007053915,0.0002336539,0.0003132955,0.0001887036,0.0005088931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002629498,0.00063754,0.006737822,0.001882823,0.0002726426,0.0001203946,0.003925534,0.00001105424,0.97797,0.00009463006,0.000586658,0.007497937],"study_design_scores_gemma":[0.005214337,0.0006853558,0.1823124,0.001041283,0.0003963422,0.00005859333,0.0007592055,0.002038899,0.8069144,0.00006195818,0.00008163493,0.0004354658],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866353,0.009210275,0.00002299725,0.001132568,0.0001518327,0.002558027,0.00008679996,0.00005633216,0.0001458155],"genre_scores_gemma":[0.9905471,0.008141284,0.00009356363,0.0006859411,0.00009705564,0.0002759229,0.00007222086,0.00006327272,0.00002360644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1755746,"threshold_uncertainty_score":0.9996695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01146323640881426,"score_gpt":0.276127980271634,"score_spread":0.2646647438628197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}