{"id":"W1926467922","doi":"10.1002/bdd.1856","title":"Comparative effects of 1α‐hydroxyvitamin D<sub>3</sub> and 1,25‐dihydroxyvitamin D<sub>3</sub> on transporters and enzymes in <i>fxr(+/+)</i> and <i>fxr(‐/‐)</i> mice","year":2013,"lang":"en","type":"article","venue":"Biopharmaceutics & Drug Disposition","topic":"Vitamin D Research Studies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Calcitriol receptor; Farnesoid X receptor; Cholesterol 7 alpha-hydroxylase; Internal medicine; Endocrinology; CYP24A1; Bile acid; TRPV6; Chemistry; Vitamin D and neurology; Enterohepatic circulation; Receptor; Nuclear receptor; Biology; Medicine; Biochemistry; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004773433,0.0007095785,0.0009597336,0.001259027,0.0003152589,0.0006487308,0.0004324707,0.001119357,0.002338219],"category_scores_gemma":[0.0002672182,0.0006020769,0.001035074,0.0005157937,0.001035447,0.000607402,0.0002339816,0.002112682,0.0006094458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000636489,"about_ca_system_score_gemma":0.0004807376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00149743,"about_ca_topic_score_gemma":0.002327638,"domain_scores_codex":[0.999217,0.0001305561,0.0001018638,0.0002259708,0.0001445405,0.0001800363],"domain_scores_gemma":[0.9987628,0.0001740845,0.0003165527,0.000123164,0.0001081359,0.0005152457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005953955,0.0004419294,0.0004208304,0.00006756485,0.00003952465,0.00009540701,0.00005176278,0.0001545195,0.990864,0.0001528017,0.00008165716,0.001676072],"study_design_scores_gemma":[0.0003101365,0.006199935,0.005983601,0.000009900346,0.0001336176,0.0001993653,0.0001347387,0.0006059537,0.9842231,0.0001496104,0.002020934,0.00002908991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918572,0.001817784,0.001662703,0.0002645865,0.00009161637,0.00008412251,0.002142294,0.000194666,0.001885071],"genre_scores_gemma":[0.9788087,0.001871687,0.003596432,0.0003538664,0.00006044532,0.000246106,0.002336685,0.0001700582,0.012556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002338219,"threshold_uncertainty_score":0.007822156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01146323640881426,"score_gpt":0.276127980271634,"score_spread":0.2646647438628197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}