{"id":"W1926903137","doi":"10.1139/cjc-2013-0053","title":"Synthesis and antiproliferative and c-Src kinase inhibitory activities of cinnamoyl- and pyranochromen-2-one derivatives","year":2013,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Synthesis of Organic Compounds","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"American Cancer Society; National Science Foundation","keywords":"Chemistry; Chalcone; Proto-oncogene tyrosine-protein kinase Src; Kinase; Flavanone; Stereochemistry; Cell culture; Cell growth; Cancer cell; Cancer cell lines; Cancer; Cancer research; Biochemistry; Flavonoid; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001144583,0.0003058932,0.0001858522,0.0003435053,0.0001093183,0.0001808199,0.0002555316,0.000215576,0.001748816],"category_scores_gemma":[0.0000896036,0.0001041112,0.0001878508,0.000291633,0.0001258167,0.0001908006,0.0001250557,0.0002490541,0.0002157008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002842481,"about_ca_system_score_gemma":0.0003528567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001482553,"about_ca_topic_score_gemma":0.003465503,"domain_scores_codex":[0.9999446,0.000007645011,0.000004373604,0.000009918131,0.00001475908,0.00001866699],"domain_scores_gemma":[0.9999524,0.000005108569,0.000008377417,0.000005131283,0.00001595397,0.00001301956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001645998,0.0001030255,0.0001278341,0.000275861,0.00001702734,0.0001769124,0.00005553454,0.0007635899,0.986529,0.000635618,0.0001197686,0.01103113],"study_design_scores_gemma":[0.00008180751,0.001639738,0.003012742,0.00001874216,0.00005396354,0.0002579632,0.00003441633,0.0007735403,0.983937,0.000118461,0.01004895,0.00002273266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9741726,0.00885909,0.005547505,0.0001578869,0.00007369256,0.0002637721,0.000949705,0.0001038375,0.00987181],"genre_scores_gemma":[0.9845835,0.004634171,0.004269544,0.00009926652,0.00001677105,0.00007006674,0.000743652,0.00001162786,0.005571351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001748816,"threshold_uncertainty_score":0.005850434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009599744685438503,"score_gpt":0.2033290937081225,"score_spread":0.193729349022684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}