{"id":"W1927022149","doi":"","title":"Chondrocyte death in experimental osteoarthritis is mediated by MEK 1/2 and p38 pathways: role of cyclooxygenase-2 and inducible nitric oxide synthase.","year":2001,"lang":"en","type":"article","venue":"PubMed","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Hôpital Notre-Dame","funders":"","keywords":"Nitric oxide synthase; Chondrocyte; p38 mitogen-activated protein kinases; Nitrotyrosine; Medicine; Cartilage; Apoptosis; Cyclooxygenase; Osteoarthritis; Nitric oxide; MAPK/ERK pathway; Pharmacology; Kinase; Endocrinology; Cell biology; Chemistry; Biology; Pathology; Biochemistry; Enzyme; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002425754,0.0005457464,0.0002663735,0.0002617747,0.0001534617,0.0001997168,0.0001895523,0.0002861033,0.00104318],"category_scores_gemma":[0.0001356384,0.0001958924,0.0002784448,0.00009795489,0.000296697,0.0002912256,0.0001640266,0.0003744444,0.0002371358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002708536,"about_ca_system_score_gemma":0.0003221486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004121707,"about_ca_topic_score_gemma":0.000906672,"domain_scores_codex":[0.9998639,0.00002372702,0.00001147637,0.00001872656,0.00003969915,0.00004257968],"domain_scores_gemma":[0.9998801,0.00001327563,0.00004560536,0.000009373338,0.00001936619,0.00003234904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000821318,0.0001144813,0.0007192263,0.0001581452,0.000009171674,0.0001152557,0.00002272994,0.00003518019,0.9959991,0.0000552053,0.00003887991,0.001911478],"study_design_scores_gemma":[0.0001999354,0.004168468,0.03023177,0.00003444354,0.00008547782,0.001222781,0.0001469777,0.001176494,0.9604302,0.0001166899,0.002175381,0.00001129006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903779,0.006802282,0.001850357,0.0001003446,0.00004064114,0.00005044461,0.0001376064,0.00003694794,0.0006035155],"genre_scores_gemma":[0.9936005,0.002925494,0.00163241,0.00003366618,0.0000223759,0.00008710557,0.0002151864,0.000003879958,0.001479421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00104318,"threshold_uncertainty_score":0.003489733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01711387227323387,"score_gpt":0.2154855104406501,"score_spread":0.1983716381674163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}