{"id":"W1927148119","doi":"10.1002/bit.25163","title":"Real‐time monitoring and control of soluble signaling factors enables enhanced progenitor cell outputs from human cord blood stem cell cultures","year":2013,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Heart and Stroke Foundation; Discovery Centre; University Health Network; University of Toronto","funders":"Networks of Centres of Excellence of Canada; Natural Sciences and Engineering Research Council of Canada; Leukemia and Lymphoma Society","keywords":"Progenitor cell; Cell biology; Cell culture; Haematopoiesis; Stem cell; Bioreactor; Cell growth; Cell; Biology; Cell fate determination; Transcription factor; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000184422,0.0002682758,0.0002086419,0.0001627558,0.0001021962,0.0004278545,0.0001612766,0.0001448936,0.0006090355],"category_scores_gemma":[0.0001482918,0.0001225849,0.0001270605,0.0001549284,0.0001674887,0.0001239441,0.0001813335,0.0003609402,0.0002317892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004097627,"about_ca_system_score_gemma":0.0002471605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008338935,"about_ca_topic_score_gemma":0.001392152,"domain_scores_codex":[0.999841,0.00001512243,0.00001365437,0.00004389851,0.00007032377,0.00001595441],"domain_scores_gemma":[0.9999088,0.00002522741,0.00002380569,0.000009143448,0.00001889966,0.00001401992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000173108,0.000004264426,0.00008571807,0.000009628746,7.290272e-7,0.00001027898,0.00001175399,0.00007641874,0.998459,0.00003535726,0.00001728478,0.001272348],"study_design_scores_gemma":[0.000001454546,0.00002048352,0.000377347,8.060729e-7,0.00000159894,0.00001161654,0.00000344623,0.000721484,0.9984031,0.000009948621,0.0004477016,0.000001115358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9439024,0.0009564328,0.05219035,0.00007825597,0.00003408547,0.00009145561,0.0006181579,0.000486841,0.001642031],"genre_scores_gemma":[0.9586291,0.0007963607,0.03729928,0.0000487075,0.00001149702,0.00009567995,0.0004161538,0.00006754207,0.002635553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008338935,"threshold_uncertainty_score":0.00297308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005155398940307887,"score_gpt":0.2072171969533781,"score_spread":0.2020617980130702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}