{"id":"W1927155785","doi":"10.1186/s13287-015-0149-3","title":"Induced pluripotent stem cell models of Zellweger spectrum disorder show impaired peroxisome assembly and cell type-specific lipid abnormalities","year":2015,"lang":"en","type":"article","venue":"Stem Cell Research & Therapy","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Global Foundation for Peroxisomal Disorders; McGill University; National Institute of General Medical Sciences; California Institute of Regenerative Medicine; University of Southern California","keywords":"Induced pluripotent stem cell; Biology; Reprogramming; Zellweger syndrome; Cell biology; Cell type; Stem cell; Cellular differentiation; Molecular biology; Peroxisome; Cell; Genetics; Gene; Embryonic stem cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001638356,0.0005423703,0.0002088391,0.0006244143,0.0001969109,0.0002858911,0.0002057206,0.0003930535,0.003696553],"category_scores_gemma":[0.000144349,0.0001495441,0.0002632037,0.0003104965,0.0003012883,0.0001758778,0.0003034298,0.0003996961,0.0006733734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001893645,"about_ca_system_score_gemma":0.0001295709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003564252,"about_ca_topic_score_gemma":0.0006989001,"domain_scores_codex":[0.99984,0.00001606371,0.00003610993,0.00004003414,0.00005213957,0.00001563933],"domain_scores_gemma":[0.9999068,0.00001732537,0.00003117826,0.00001881519,0.000009295278,0.00001651216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001419396,0.00004490426,0.001922153,0.0000756142,0.00003738215,0.0009686674,0.00009188072,0.0002834258,0.9919747,0.0006660015,0.0002449568,0.003548508],"study_design_scores_gemma":[0.0001010367,0.0007202888,0.02564166,0.00004267605,0.0001558682,0.009747873,0.0001814281,0.001948062,0.949038,0.0006624569,0.01173568,0.00002498907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847365,0.001183552,0.008683317,0.0001091104,0.00005402676,0.0001244426,0.00194634,0.0002173606,0.002945377],"genre_scores_gemma":[0.9890192,0.0008093417,0.003436845,0.00006656216,0.000008603336,0.0001005315,0.003244586,0.00004003791,0.00327433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003696553,"threshold_uncertainty_score":0.01236624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0768095363967225,"score_gpt":0.2943327199993671,"score_spread":0.2175231836026446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}