{"id":"W1927371034","doi":"10.1080/21645515.2015.1094595","title":"Recombinant and epitope-based vaccines on the road to the market and implications for vaccine design and production","year":2015,"lang":"en","type":"article","venue":"Human Vaccines & Immunotherapeutics","topic":"vaccines and immunoinformatics approaches","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Lethbridge","keywords":"Epitope; Biology; Virology; Bioprocess; Computational biology; HIV vaccine; Vaccination; DNA vaccination; Population; Reverse vaccinology; Immunology; Immune system; Medicine; Vaccine trial; Antibody; Immunization","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008340483,0.0002551866,0.00019392,0.00005726786,0.0005005642,0.0001428592,0.0002368709,0.00009156648,0.000004172176],"category_scores_gemma":[0.0001180741,0.0001505481,0.00004386326,0.0001103246,0.00002504557,0.00001385525,0.0001078144,0.00009583002,0.000001264473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001356809,"about_ca_system_score_gemma":0.00004093104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001520801,"about_ca_topic_score_gemma":0.00002523121,"domain_scores_codex":[0.9989451,0.00009696582,0.0003191023,0.0003204264,0.0000707512,0.0002476335],"domain_scores_gemma":[0.998889,0.0000797326,0.0001363818,0.0006430545,0.0001837104,0.00006817407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006242495,0.0008525921,0.0190342,0.0003766816,0.001260665,5.343601e-7,0.00373706,0.001329661,0.4336687,0.007795969,0.1707665,0.354935],"study_design_scores_gemma":[0.01056001,0.007462689,0.3150261,0.0001930275,0.0005416145,0.0001993098,0.002121374,0.008004478,0.07390978,0.007948687,0.5721877,0.001845179],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9418973,0.008240733,0.007758202,0.0388427,0.0002869916,0.002831233,0.00001530018,0.00003337114,0.00009412905],"genre_scores_gemma":[0.9920337,0.001376778,0.002396632,0.002487379,0.0002615642,0.0004562082,0.00004574738,0.00006290684,0.0008791285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4014212,"threshold_uncertainty_score":0.6139173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05749495101406384,"score_gpt":0.2856111812547643,"score_spread":0.2281162302407005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}