{"id":"W1927946859","doi":"10.4049/jimmunol.1202711","title":"Separation of Function between Isotype Switching and Affinity Maturation In Vivo during Acute Immune Responses and Circulating Autoantibodies in UNG-Deficient Mice","year":2013,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Institut National de la Recherche Scientifique; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Immunoglobulin class switching; Somatic hypermutation; Affinity maturation; Isotype; Germinal center; Biology; Immunology; In vivo; Antibody; Immune system; B cell; Genetics; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003765953,0.001113201,0.0004916307,0.001356902,0.0002554688,0.0007415168,0.000736843,0.001143978,0.001686051],"category_scores_gemma":[0.0003237422,0.000605649,0.000425261,0.0003038421,0.0007912929,0.0007314793,0.0005411261,0.001313792,0.000750491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005154894,"about_ca_system_score_gemma":0.0002624117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002895355,"about_ca_topic_score_gemma":0.0004684303,"domain_scores_codex":[0.9995858,0.00007185189,0.00006136482,0.000124123,0.00007522829,0.00008164887],"domain_scores_gemma":[0.9992608,0.0001167278,0.0002544052,0.00008409579,0.00002498354,0.0002588669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008839617,0.0001027728,0.0006110564,0.00005189003,0.00001218531,0.0001324601,0.00003185275,0.0001113438,0.9957107,0.0004103015,0.00004974502,0.001891725],"study_design_scores_gemma":[0.0003222524,0.001752046,0.01386015,0.00006534404,0.00009640842,0.001704987,0.00008060728,0.002254031,0.9762231,0.0009820418,0.002633088,0.00002602197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909734,0.002088292,0.00366923,0.0002437567,0.00003401721,0.00005306493,0.001064456,0.0003327714,0.001540965],"genre_scores_gemma":[0.9892235,0.00106037,0.005238676,0.0002463817,0.00003184765,0.0001197483,0.0009219116,0.0002169057,0.002940647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001686051,"threshold_uncertainty_score":0.005640447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01093690658520619,"score_gpt":0.2418645588984822,"score_spread":0.2309276523132761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}