{"id":"W1928502853","doi":"10.1039/c5md00152h","title":"Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains","year":2015,"lang":"en","type":"article","venue":"MedChemComm","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Ministero dello Sviluppo Economico; Ontario Ministry of Economic Development and Innovation; British Heart Foundation; Wellcome Trust; Genome Canada; Directorate for Biological Sciences; Wellcome; GlaxoSmithKline; European Commission; Pfizer; Eli Lilly and Company","keywords":"Bromodomain; Chemistry; Computational biology; Pharmacology; Biology; Biochemistry; Acetylation; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003730482,0.0006068931,0.000508328,0.0003337656,0.0003140395,0.0003568432,0.0007219745,0.0004843645,0.001966371],"category_scores_gemma":[0.00019338,0.0003548081,0.0003719972,0.0002338409,0.0002242008,0.0003536666,0.0003373784,0.001014528,0.001297627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005921286,"about_ca_system_score_gemma":0.0005341559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004369286,"about_ca_topic_score_gemma":0.001612279,"domain_scores_codex":[0.9998191,0.00002125236,0.00002055438,0.00002820656,0.00005390846,0.00005710308],"domain_scores_gemma":[0.9999131,0.00001003719,0.00001754874,0.000008392976,0.00002224792,0.00002870484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002066636,0.0001927448,0.0001270386,0.0004062198,0.00003171478,0.0002061494,0.00005709721,0.00126342,0.9749984,0.002698806,0.001430471,0.01838128],"study_design_scores_gemma":[0.0001360749,0.0005744797,0.0002535188,0.00001534209,0.00003413384,0.0003587372,0.00001900672,0.00123662,0.9608014,0.0001986104,0.03635431,0.00001778869],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6623991,0.03878577,0.2444165,0.002302874,0.000953639,0.003985103,0.004467385,0.001501936,0.04118768],"genre_scores_gemma":[0.8480572,0.0278595,0.09532089,0.0009273982,0.0001204614,0.001493863,0.004840946,0.000121217,0.02125855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001966371,"threshold_uncertainty_score":0.006578147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01581447698278131,"score_gpt":0.2289470474945028,"score_spread":0.2131325705117215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}