{"id":"W1929242319","doi":"10.1038/emboj.2011.96","title":"Constitutive heterochromatin reorganization during somatic cell reprogramming","year":2011,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":153,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Biology; Reprogramming; Somatic cell; Constitutive heterochromatin; Heterochromatin; Genetics; Cell biology; Chromatin; Cell; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002203375,0.0001813821,0.000201818,0.0002084742,0.0001527804,0.0005798747,0.0003845929,0.0002978528,0.00159257],"category_scores_gemma":[0.0001800438,0.0003016341,0.0002107948,0.0002140375,0.0003322148,0.0003727402,0.0005015341,0.0005836831,0.0006510228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003603462,"about_ca_system_score_gemma":0.0001489444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002433623,"about_ca_topic_score_gemma":0.0005624088,"domain_scores_codex":[0.9997763,0.00002781708,0.00001951235,0.00006853847,0.00005764702,0.00005013521],"domain_scores_gemma":[0.9997866,0.00005516024,0.00004637513,0.0000699532,0.0000134848,0.0000284894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003726068,0.000007108173,0.00008900011,0.00001280559,0.00000218568,0.00003375043,0.00001104326,0.00004322266,0.9983373,0.00031316,0.00002032842,0.001092947],"study_design_scores_gemma":[0.00001511061,0.00003281582,0.003831483,0.000004017445,0.000009887962,0.0003157295,0.00002175278,0.0006793261,0.9926869,0.0001415763,0.002256181,0.00000521798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783507,0.001699239,0.01211961,0.000126487,0.00005558902,0.00005271004,0.0004620449,0.0002964543,0.006837068],"genre_scores_gemma":[0.9947154,0.0003414539,0.001256885,0.00004013106,0.000009619853,0.00002146857,0.0002698249,0.00007990307,0.003265349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00159257,"threshold_uncertainty_score":0.005327702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01758553374700465,"score_gpt":0.2352744140130683,"score_spread":0.2176888802660636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}