{"id":"W1932180873","doi":"10.1177/1074248415591698","title":"Epigenetic Therapy for the Treatment of Hypertension-Induced Cardiac Hypertrophy and Fibrosis","year":2015,"lang":"en","type":"article","venue":"Journal of Cardiovascular Pharmacology and Therapeutics","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University; University College Dublin; Queen's University Belfast","keywords":"Epigenetics; Medicine; Fibrosis; Muscle hypertrophy; Cardiac fibrosis; Fibroblast; Myocyte; Myocardial fibrosis; Internal medicine; DNA methylation; Cardiac myocyte; Extracellular matrix; Myofibroblast; Endocrinology; Cancer research; Biology; Cell biology; Cell culture; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005966375,0.0001557746,0.0008329652,0.00007599025,0.00008553591,0.00001044717,0.0000474013,0.0001118508,0.00000149568],"category_scores_gemma":[0.000008349881,0.00008326169,0.001023152,0.00007408626,0.0001192141,0.00003329352,0.0000113608,0.0001067413,1.729733e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003397399,"about_ca_system_score_gemma":0.0001218362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008859192,"about_ca_topic_score_gemma":6.602753e-8,"domain_scores_codex":[0.9990132,0.0001369157,0.0003221266,0.0001295803,0.0002422362,0.0001559342],"domain_scores_gemma":[0.9988815,0.0002402639,0.0001307085,0.0001738316,0.0004425407,0.0001311653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00402525,0.000484795,0.002730692,0.00007303399,0.0375173,0.00002397562,0.001492261,0.001380015,0.3899301,0.00001906695,0.0002042466,0.5621193],"study_design_scores_gemma":[0.0345998,0.01579207,0.02934998,0.00009330404,0.0332946,0.001685087,0.001132562,0.004267382,0.2234026,0.0002669199,0.6556969,0.0004187755],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6981324,0.2998265,0.000452486,0.0005011124,0.0006863769,0.000377921,0.000004154822,0.000003315927,0.00001573454],"genre_scores_gemma":[0.832922,0.1655566,0.0005982984,0.0002611153,0.0006233998,0.000009439847,8.330086e-7,0.00001874491,0.00000965215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6554927,"threshold_uncertainty_score":0.3395313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0786629978083411,"score_gpt":0.3099169309836328,"score_spread":0.2312539331752917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}