{"id":"W1932916050","doi":"10.1161/circresaha.117.305784","title":"Dicer Cleavage by Calpain Determines Platelet microRNA Levels and Function in Diabetes","year":2015,"lang":"en","type":"article","venue":"Circulation Research","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Deutsches Zentrum für Herz-Kreislaufforschung","keywords":"Dicer; Platelet; Calpain; microRNA; Endocrinology; Diabetes mellitus; Drosha; Internal medicine; Thrombin; Downregulation and upregulation; Knockout mouse; Biology; Cell biology; Chemistry; Medicine; RNA; RNA interference; Biochemistry; Receptor; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001142691,0.00008901783,0.00008652006,0.0001414358,0.00008627362,0.0000532934,0.00005631377,0.0001706884,0.00002019036],"category_scores_gemma":[0.0002610984,0.00008716312,0.00002435038,0.0002058418,0.0001053559,0.00001372509,0.00006038775,0.0001314151,0.00001565551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000418076,"about_ca_system_score_gemma":0.00005902961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005656534,"about_ca_topic_score_gemma":0.00006777204,"domain_scores_codex":[0.9987734,0.0002645499,0.0001718611,0.0003026901,0.0002520132,0.0002354834],"domain_scores_gemma":[0.9994843,0.00003241406,0.00003415271,0.0001686493,0.0001552002,0.000125276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000115478,0.00005455499,0.1169096,0.00002715541,0.00001505558,0.000001619537,0.00007637227,0.0002575376,0.8502985,0.00003119239,0.01400719,0.01820574],"study_design_scores_gemma":[0.004043451,0.000516266,0.6448874,0.00005620654,0.00001085376,0.00001440866,0.000425163,0.01503802,0.225418,0.00161036,0.1074594,0.0005204185],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968518,0.0007488257,0.001246454,0.0003273134,0.00009284577,0.00029286,0.000009073789,0.00001236691,0.0004184687],"genre_scores_gemma":[0.9987612,0.00001417294,0.00003343438,0.0001125653,0.0001435212,0.00003917264,0.000169911,0.0000156899,0.0007103659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6248805,"threshold_uncertainty_score":0.3554409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05912027874331845,"score_gpt":0.3243613915175921,"score_spread":0.2652411127742736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}