{"id":"W1932916050","doi":"10.1161/circresaha.117.305784","title":"Dicer Cleavage by Calpain Determines Platelet microRNA Levels and Function in Diabetes","year":2015,"lang":"en","type":"article","venue":"Circulation Research","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Deutsches Zentrum für Herz-Kreislaufforschung","keywords":"Dicer; Platelet; Calpain; microRNA; Endocrinology; Diabetes mellitus; Drosha; Internal medicine; Thrombin; Downregulation and upregulation; Knockout mouse; Biology; Cell biology; Chemistry; Medicine; RNA; RNA interference; Biochemistry; Receptor; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002766845,0.0002509082,0.0002674734,0.0002967714,0.0001509862,0.0004866628,0.0001563288,0.0003371446,0.0009295107],"category_scores_gemma":[0.0003495754,0.0001570072,0.0002316584,0.0002323036,0.0002505295,0.0001958449,0.0001534488,0.000788261,0.0001833155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003264927,"about_ca_system_score_gemma":0.0001459793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000288236,"about_ca_topic_score_gemma":0.0002683073,"domain_scores_codex":[0.9998296,0.00002322079,0.0000212112,0.00005458347,0.00004349911,0.00002777088],"domain_scores_gemma":[0.9997877,0.00002971419,0.0001004129,0.00001472958,0.00002594136,0.00004137131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001323459,0.00005562704,0.008184596,0.00007759808,0.00002682506,0.0002444618,0.0000445299,0.00007271182,0.985816,0.0001485187,0.0001532047,0.003852472],"study_design_scores_gemma":[0.0001457843,0.0009295355,0.167014,0.0000295937,0.0001632239,0.002912848,0.0001245597,0.001772034,0.8235501,0.0003439797,0.002994142,0.00002021332],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925153,0.003407177,0.002410006,0.0001465835,0.00003412715,0.00002847766,0.0004568169,0.00004865196,0.000952933],"genre_scores_gemma":[0.996174,0.001115619,0.001659541,0.00009191451,0.00001671854,0.00002501792,0.00040528,0.00001107445,0.0005009237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009295107,"threshold_uncertainty_score":0.003109515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05912027874331845,"score_gpt":0.3243613915175921,"score_spread":0.2652411127742736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}