{"id":"W1933880153","doi":"10.1016/j.freeradbiomed.2015.10.404","title":"ROS-dependent activation of autophagy is a critical mechanism for the induction of anti-glioma effect of sanguinarine","year":2015,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Terry Fox Foundation; National Research Foundation; Al Jalila Foundation; Sheikh Hamdan Bin Rashid Al Maktoum Award for Medical Sciences; Utah Agricultural Experiment Station","keywords":"Autophagy; Programmed cell death; ATG5; Cell biology; Apoptosis; Chemistry; Cancer research; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001941341,0.0004046167,0.0003727029,0.0003053955,0.0001997126,0.0001521553,0.0002307556,0.000280121,0.001145014],"category_scores_gemma":[0.000129061,0.0001221421,0.0005837973,0.000161278,0.000233537,0.0002276633,0.0002112866,0.0004455908,0.0002064479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002154164,"about_ca_system_score_gemma":0.0002933082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008256107,"about_ca_topic_score_gemma":0.001541428,"domain_scores_codex":[0.9998939,0.0000309043,0.00001427305,0.00001296841,0.00001686037,0.00003112798],"domain_scores_gemma":[0.9999456,0.000009058526,0.00001219508,0.00001129162,0.000009976684,0.00001188858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001264111,0.00007034373,0.0003060933,0.0001421824,0.00003066705,0.0001352358,0.00003075855,0.000072375,0.9945853,0.0002369335,0.0001091836,0.003016743],"study_design_scores_gemma":[0.00007614278,0.0008056094,0.004333143,0.00001115526,0.00005268957,0.0001820767,0.00003279201,0.000298527,0.9918087,0.0001074914,0.002284047,0.000007491345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915413,0.00453731,0.001395983,0.0001829979,0.00006721899,0.00004066103,0.0001753595,0.00008313128,0.001975935],"genre_scores_gemma":[0.9973949,0.001058848,0.000524299,0.00004922821,0.00001042665,0.00001878809,0.000160047,0.000007177852,0.0007762057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001145014,"threshold_uncertainty_score":0.003830433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02839903823307338,"score_gpt":0.3544785356694156,"score_spread":0.3260794974363422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}