{"id":"W1933897339","doi":"10.1002/9780470559277.ch140202","title":"SNIPER Peptide‐Mediated Degradation of Endogenous Proteins","year":2015,"lang":"en","type":"article","venue":"Current Protocols in Chemical Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Coastal Health Research Institute; University of British Columbia; Vancouver Coastal Health","funders":"Canadian Institutes of Health Research","keywords":"Endogeny; Peptide; Intracellular; Cell biology; Gene knockdown; Autophagy; Chaperone (clinical); Protein degradation; Function (biology); Biology; Computational biology; Chemistry; Biochemistry; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002277341,0.0001371629,0.0001924098,0.00004738219,0.000009552431,0.000003993947,0.000194875,0.000174006,0.00000867552],"category_scores_gemma":[0.0004648054,0.0001242666,0.00005132661,0.0001098616,0.00009123362,0.000002354522,0.0001091027,0.0001510557,0.000006686151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002231078,"about_ca_system_score_gemma":0.00009474639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007863057,"about_ca_topic_score_gemma":0.000003987208,"domain_scores_codex":[0.9990255,0.00005748455,0.0003222263,0.0002824996,0.00007475063,0.0002375897],"domain_scores_gemma":[0.9994898,0.00001782374,0.00007660282,0.0002379173,0.0000872057,0.00009062876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008667844,0.0001392675,0.008006636,0.0000595509,0.000007680096,5.110911e-7,0.00002960662,0.00002027863,0.985027,0.00005805702,0.0001584574,0.006406298],"study_design_scores_gemma":[0.001030343,0.0002575263,0.0001223916,0.00004129896,0.000003194917,0.000008125278,0.00001594991,0.00006488316,0.9660341,0.0001550869,0.03211905,0.0001480119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9720375,0.0009411869,0.006000003,0.00004479249,0.0001677487,0.01998032,0.0000428678,0.00002593797,0.000759633],"genre_scores_gemma":[0.98171,0.00002407303,0.001380933,0.0000146101,0.0001500091,0.01635796,0.0003317071,0.00001553913,0.00001517875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0319606,"threshold_uncertainty_score":0.5067443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06601285111260946,"score_gpt":0.392490521902483,"score_spread":0.3264776707898735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}