{"id":"W1933897339","doi":"10.1002/9780470559277.ch140202","title":"SNIPER Peptide‐Mediated Degradation of Endogenous Proteins","year":2015,"lang":"en","type":"article","venue":"Current Protocols in Chemical Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Coastal Health Research Institute; University of British Columbia; Vancouver Coastal Health","funders":"Canadian Institutes of Health Research","keywords":"Endogeny; Peptide; Intracellular; Cell biology; Gene knockdown; Autophagy; Chaperone (clinical); Protein degradation; Function (biology); Biology; Computational biology; Chemistry; Biochemistry; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003401844,0.0003953966,0.0002638841,0.0001141006,0.000200981,0.0002237092,0.0003483788,0.0003121399,0.0007619395],"category_scores_gemma":[0.0001679753,0.000131093,0.0001899093,0.00009653005,0.000321568,0.0002833482,0.0002430854,0.000567004,0.0003957048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002880407,"about_ca_system_score_gemma":0.0003031667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000312306,"about_ca_topic_score_gemma":0.0005710527,"domain_scores_codex":[0.9997721,0.00002673448,0.00002153446,0.00006761325,0.00007159535,0.00004032569],"domain_scores_gemma":[0.9998658,0.00003440055,0.00004487628,0.00002104681,0.00001911698,0.00001470939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003490425,0.000008740913,0.00002595705,0.00004930656,0.000003098753,0.00003711636,0.00001424846,0.0001121316,0.9977266,0.000209393,0.00006612529,0.001712485],"study_design_scores_gemma":[0.000003387607,0.00004958677,0.0001458618,0.000002156952,0.000001775455,0.00007319467,0.000004105577,0.0003596158,0.99786,0.00002197311,0.00147617,0.000002274408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9258507,0.002656583,0.06415376,0.0001697892,0.00008245506,0.0001222715,0.0004906061,0.0004178908,0.006056001],"genre_scores_gemma":[0.9563422,0.001918848,0.03260314,0.0001393374,0.00001629229,0.000123967,0.0008453088,0.00008478572,0.007926131],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.0007619395,"threshold_uncertainty_score":0.002548873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06601285111260946,"score_gpt":0.392490521902483,"score_spread":0.3264776707898735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}