{"id":"W1934544675","doi":"10.1111/j.1365-2958.2004.04258.x","title":"RNase HI overproduction is required for efficient full‐length RNA synthesis in the absence of topoisomerase I in <i>Escherichia coli</i>","year":2004,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Fonds De La Recherche Scientifique - FNRS","keywords":"DNA gyrase; DNA supercoil; Biology; RNase P; Topoisomerase; Overproduction; RNA; Mutant; Escherichia coli; RNase H; Molecular biology; Ribonuclease III; DNA; Cell biology; Biochemistry; Enzyme; Gene; DNA replication; RNA interference","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003454686,0.0001675647,0.000215566,0.00007291968,0.00003548458,0.000008011413,0.0002526081,0.0001745942,0.000007009425],"category_scores_gemma":[0.00005508164,0.0001445094,0.0001204885,0.0001795562,0.00009862782,0.000002109934,0.00004995823,0.00009239918,0.000001954403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004837582,"about_ca_system_score_gemma":0.00009894379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001140456,"about_ca_topic_score_gemma":0.0001048353,"domain_scores_codex":[0.9988354,0.00009466317,0.000301467,0.0004202199,0.0000498298,0.0002983873],"domain_scores_gemma":[0.9993727,0.00002042303,0.0001150439,0.0004103245,0.00005514959,0.00002638038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002839176,0.0001919665,0.000008712571,0.00002738756,0.00002817674,0.000007066122,0.0002175436,0.0009598735,0.9967222,0.0006362589,0.00004396894,0.0008729124],"study_design_scores_gemma":[0.001022328,0.0003500673,0.00004267511,0.00002838366,0.00001592233,0.00002290218,0.0001221215,0.00002776568,0.9915944,0.0003110616,0.006297199,0.0001651395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990806,0.001299651,0.006177029,0.0008485254,0.0001881033,0.0005358548,0.00008189677,0.000004317355,0.00005860657],"genre_scores_gemma":[0.9968507,0.0001715564,0.001044246,0.001676997,0.00004615461,0.0001225045,0.00005275993,0.00002031184,0.00001472821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00625323,"threshold_uncertainty_score":0.5892923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008514061667664474,"score_gpt":0.2361126846192843,"score_spread":0.2275986229516198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}