{"id":"W1934544675","doi":"10.1111/j.1365-2958.2004.04258.x","title":"RNase HI overproduction is required for efficient full‐length RNA synthesis in the absence of topoisomerase I in <i>Escherichia coli</i>","year":2004,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Fonds De La Recherche Scientifique - FNRS","keywords":"DNA gyrase; DNA supercoil; Biology; RNase P; Topoisomerase; Overproduction; RNA; Mutant; Escherichia coli; RNase H; Molecular biology; Ribonuclease III; DNA; Cell biology; Biochemistry; Enzyme; Gene; DNA replication; RNA interference","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002137436,0.0004747321,0.0003610274,0.0002050761,0.0001156933,0.000623818,0.0002401547,0.0003199565,0.000727393],"category_scores_gemma":[0.000318458,0.0003398439,0.000246339,0.000116018,0.0003170826,0.0002612329,0.0002645721,0.0005931355,0.0006969968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003383686,"about_ca_system_score_gemma":0.0002952199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009060251,"about_ca_topic_score_gemma":0.001028752,"domain_scores_codex":[0.9997144,0.00006035822,0.00003326197,0.0000427419,0.00009244726,0.00005675778],"domain_scores_gemma":[0.9994256,0.0001575681,0.0001752018,0.00007662642,0.00004214958,0.000122729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002674438,0.000007208737,0.00007171008,0.0000104828,0.00000147187,0.00003418858,0.000004327514,0.00001843493,0.99961,0.00001914091,0.000009965824,0.0001863606],"study_design_scores_gemma":[0.000007812895,0.0001515125,0.004943247,0.000004758768,0.000006872679,0.0002802863,0.00002730304,0.0004801671,0.9932917,0.00003607433,0.0007650744,0.000005100527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995103,0.001245504,0.00226029,0.0001261047,0.00002787104,0.00001492591,0.0003362189,0.0001930572,0.0006930123],"genre_scores_gemma":[0.9947166,0.0005186796,0.002318195,0.00005837233,0.0000161365,0.00001874508,0.0007850165,0.00009739801,0.001470823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009060251,"threshold_uncertainty_score":0.002455115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008514061667664474,"score_gpt":0.2361126846192843,"score_spread":0.2275986229516198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}