{"id":"W1934816123","doi":"10.1111/j.1476-5381.2011.01448.x","title":"Changes in aldehyde dehydrogenase 2 expression in rat blood vessels during glyceryl trinitrate tolerance development and reversal","year":2011,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Alcohol Consumption and Health Effects","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Aldehyde dehydrogenase; ALDH2; Vasodilation; Pharmacology; In vivo; Biotransformation; Blood vessel; Aorta; Drug tolerance; Chemistry; Medicine; Internal medicine; Biochemistry; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005181181,0.0001043076,0.0003714404,0.0002631304,0.00005464618,0.000007484789,0.00006540487,0.00009347445,0.0002432397],"category_scores_gemma":[0.00003904543,0.0001157424,0.00002732638,0.0001246108,0.00005102619,0.0001144239,0.00003247607,0.0004648657,0.000003058027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007387218,"about_ca_system_score_gemma":0.000184279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002353031,"about_ca_topic_score_gemma":0.0002293285,"domain_scores_codex":[0.9987917,0.0001631708,0.0004736484,0.0001563184,0.0001271255,0.000288063],"domain_scores_gemma":[0.9994482,0.00005323937,0.0002089296,0.00003106625,0.0000641213,0.0001944498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002937879,0.0007741755,0.04247687,0.0006231779,0.0000598364,0.02588209,0.002362342,0.000004623133,0.9143815,0.000001994203,0.0004002138,0.01009529],"study_design_scores_gemma":[0.01538325,0.0002542336,0.1988209,0.001203325,0.00005590654,0.009367551,0.00007005422,0.00001372622,0.7740069,0.000007270065,0.0006954203,0.0001214894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941416,0.004927984,0.000004045074,0.0002492016,0.0003288692,0.0002745349,0.000001261394,0.000008537404,0.00006395031],"genre_scores_gemma":[0.9934832,0.004415988,0.001051648,0.0008332174,0.0001442068,0.00001940938,0.000001141846,0.0000128882,0.00003828418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.156344,"threshold_uncertainty_score":0.4719836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06382738687763265,"score_gpt":0.3381261805187153,"score_spread":0.2742987936410827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}