{"id":"W1935746267","doi":"10.1016/j.jpain.2015.09.004","title":"Differences in the Antinociceptive Effects and Binding Properties of Propranolol and Bupranolol Enantiomers","year":2015,"lang":"en","type":"article","venue":"Journal of Pain","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Propranolol; Pharmacology; Antagonist; Agonist; Nociception; Blockade; Partial agonist; Enantiomer; Analgesic; Medicine; Chemistry; Receptor; Anesthesia; Internal medicine; Stereochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001629177,0.00007311349,0.0002572448,0.0001364772,0.0000223394,0.00001085031,0.00004126949,0.00003796681,8.769388e-7],"category_scores_gemma":[0.000417397,0.00003320337,0.00002739571,0.00009792523,0.00007732221,0.00006859672,0.00001140195,0.0001144148,3.467534e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001468296,"about_ca_system_score_gemma":0.00004857395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002055001,"about_ca_topic_score_gemma":0.000003401718,"domain_scores_codex":[0.9991584,0.0002901062,0.000191515,0.00005993306,0.0002044625,0.00009557498],"domain_scores_gemma":[0.9995397,0.0001298198,0.0001690288,0.00004634783,0.00006240662,0.00005267619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006085748,0.0004071786,0.7542742,0.0005447853,0.0002700608,0.0003628253,0.01763874,2.474752e-7,0.20229,0.0001201956,0.00008577299,0.0233974],"study_design_scores_gemma":[0.01927118,0.01416872,0.7745484,0.00638069,0.0006906589,0.001350266,0.04696875,0.000629384,0.1343154,0.001121559,0.0002178099,0.0003372082],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974666,0.001631251,0.00008200556,0.0005065953,0.00003686864,0.0002243805,4.23492e-7,0.000002016909,0.0000498813],"genre_scores_gemma":[0.9992271,0.0001673439,0.0004773124,0.00006557025,0.00002607477,0.000003069625,1.458667e-7,0.000004094339,0.000029266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06797464,"threshold_uncertainty_score":0.1353994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04262909798270234,"score_gpt":0.2612625441178459,"score_spread":0.2186334461351436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}