{"id":"W1936207051","doi":"10.1038/mt.2015.156","title":"Combination Therapy With Reovirus and Anti-PD-1 Blockade Controls Tumor Growth Through Innate and Adaptive Immune Responses","year":2015,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":183,"is_retracted":false,"has_abstract":false,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"National Cancer Institute; National Institute for Health and Care Research; Cancer Research UK","keywords":"Blockade; Innate immune system; Acquired immune system; Immune system; Biology; Immunology; Cancer research; Medicine; Virology; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004087063,0.0002788484,0.0004364904,0.0001098931,0.000101755,0.00005997354,0.00008259719,0.00008852642,0.00001437239],"category_scores_gemma":[0.0000296625,0.0001995559,0.00006580458,0.0002519289,0.0003232327,0.0001463907,0.00001893572,0.0001727648,0.000002370759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005640042,"about_ca_system_score_gemma":0.0001453208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003368155,"about_ca_topic_score_gemma":0.000004143523,"domain_scores_codex":[0.9985667,0.0002125993,0.0002560987,0.0003628036,0.0003367074,0.0002650862],"domain_scores_gemma":[0.9991714,0.00006454402,0.0001442064,0.0002916978,0.0002171461,0.0001109545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0642684,0.0003762588,0.004086488,0.0000169979,0.0008579774,0.0003328724,0.002331808,0.000001015212,0.9120198,0.001023679,0.00007514389,0.01460956],"study_design_scores_gemma":[0.07703633,0.01200454,0.1046262,0.0002535928,0.0001067381,0.0007647625,0.0008613431,0.0001169724,0.783968,0.002315382,0.01718517,0.0007609738],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9624818,0.03260807,0.0005758798,0.002805518,0.0000620203,0.0009322196,0.00001025493,0.00007177182,0.0004524549],"genre_scores_gemma":[0.9898602,0.005715452,0.0006858834,0.003382252,0.00003304012,0.00006235477,0.00001282694,0.00005297095,0.0001949546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1280518,"threshold_uncertainty_score":0.8137651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02642568077100044,"score_gpt":0.271333762284272,"score_spread":0.2449080815132716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}