{"id":"W1936207051","doi":"10.1038/mt.2015.156","title":"Combination Therapy With Reovirus and Anti-PD-1 Blockade Controls Tumor Growth Through Innate and Adaptive Immune Responses","year":2015,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":183,"is_retracted":false,"has_abstract":false,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"National Cancer Institute; National Institute for Health and Care Research; Cancer Research UK","keywords":"Blockade; Innate immune system; Acquired immune system; Immune system; Biology; Immunology; Cancer research; Medicine; Virology; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002387219,0.00059827,0.0008069766,0.0004297894,0.0002374303,0.0007527403,0.0004892419,0.0004526614,0.001969351],"category_scores_gemma":[0.0001856455,0.0001995848,0.0004633081,0.0002364228,0.0003473182,0.0005198546,0.000220999,0.001643326,0.0005575425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005109693,"about_ca_system_score_gemma":0.000536143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005252591,"about_ca_topic_score_gemma":0.001388296,"domain_scores_codex":[0.9997303,0.00004191945,0.00001305046,0.0000542683,0.00004742375,0.0001129405],"domain_scores_gemma":[0.9999045,0.00002122578,0.00002006462,0.00002031076,0.000006499416,0.00002737139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01305248,0.004179408,0.001456425,0.0002368798,0.0001682112,0.0001522474,0.00006854479,0.002547784,0.8662893,0.00126872,0.002380973,0.1081991],"study_design_scores_gemma":[0.003376936,0.03410755,0.007020792,0.0000435572,0.0004500374,0.0009729711,0.000129592,0.008717694,0.922312,0.0008252751,0.02198466,0.00005892626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833884,0.007598539,0.002424845,0.0003450197,0.0004876002,0.0001580947,0.0002512696,0.0003792039,0.004967161],"genre_scores_gemma":[0.9957899,0.0009841354,0.00113015,0.00006004736,0.00005776351,0.00008232901,0.0001922956,0.00002274347,0.00168069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001969351,"threshold_uncertainty_score":0.006588101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02642568077100044,"score_gpt":0.271333762284272,"score_spread":0.2449080815132716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}